Paper
Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic nephropathy.
Published Apr 1, 2016 · Yanli Cheng, Jingjing Zhang, Weiying Guo
Free radical biology & medicine
Q1 SJR score
88
Citations
4
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Non-RCT
Animal Study
Highly CitedStudy Snapshot
Fenofibrate prevents type 1 diabetic nephropathy development by up-regulating FGF21 and stimulating the Nrf2 pathway, which plays a critical role in renal protection.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
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Citations
FGF21 ameliorates diabetic nephropathy through CDK1-dependently regulating the cell cycle
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2025·0citations·Yudie Zhang et al.·Frontiers in Pharmacology
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Critical role of FGF21 in diabetic kidney disease: from energy metabolism to innate immunity
FGF21 plays a crucial role in diabetic kidney disease by maintaining glucose and lipid metabolism, regulating innate immunity, and inhibiting inflammation and fibrosis.
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Frontiers in Immunology