A validated stability-indicating LC method for the separation of enantiomer and potential impurities of Linezolid using polar organic mode

doi:10.1016/j.jpha.2012.03.006

Paper

DOI: 10.1016/j.jpha.2012.03.006

A validated stability-indicating LC method for the separation of enantiomer and potential impurities of Linezolid using polar organic mode

Published Mar 18, 2012 · T. Satyanarayana Raju, O. Vishweshwari Kutty, V. Ganesh

Journal of Pharmaceutical Analysis

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Abstract

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Study Snapshot

This stability-indicating LC method effectively separates Linezolid's enantiomer and potential impurities, enabling the determination of purity in drug substance and drug products.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Citations

DOI: 10.1002/chir.23472

Enantioseparation of linezolid and tedizolid using validated high-performance liquid chromatographic method.

The study successfully separated linezolid and tedizolid using a validated high-performance liquid chromatographic method, achieving resolution values of 4.6 and 4.8, respectively.

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Utilization of the hysteresis phenomenon for chiral high-performance liquid chromatographic method selection in polar organic mode.

The hysteresis phenomenon of amylose tris(3,5-dimethylphenylcarbamate) can extend the selectivity space of chiral HPLC methods, improving resolution, enantiomer elution order, and chemoselectivity.

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Developing an isotope dilution UHPLC-MS/MS method to quantify linezolid in human plasma: application to therapeutic drug monitoring.

The UHPLC-MS/MS assay effectively quantifies linezolid in human plasma, aiding in therapeutic drug monitoring and optimizing dosing regimens for ICU patients.

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Bioanalysis

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Method Development and Validation for the Simultaneous Estimation of Cefuroxime Axetil and Linezolid in Pharmaceutical Dosage form by RP-HPLC and HPTLC Method

The developed RP-HPLC and HPTLC methods are simple, fast, reproducible, and sensitive for simultaneous estimation of Cefuroxime axetil and Linezolid in pharmaceutical tablet dosage forms, aiding in routine quality control.

2017·0citations·A. R. Prasanth

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Simultaneous determination and stability studies of linezolid, meropenem and vancomycin in bacterial growth medium by high-performance liquid chromatography.

The developed HPLC assay accurately quantifies linezolid, vancomycin, and meropenem in bacterial growth medium, allowing for valid PK/PD assessment in in vitro infection models.

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