Valsartan reverses depressive/anxiety-like behavior and induces hippocampal neurogenesis and expression of BDNF protein in unpredictable chronic mild stress mice

doi:10.1016/j.pbb.2014.05.006

Paper

Valsartan reverses depressive/anxiety-like behavior and induces hippocampal neurogenesis and expression of BDNF protein in unpredictable chronic mild stress mice

Published Sep 1, 2014 · Gu Ping, W. Qian, G. Song

Pharmacology Biochemistry and Behavior

Q1 SJR score

65

Citations

4

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Valsartan effectively reduces depressive/anxiety symptoms and promotes hippocampal neurogenesis and BDNF expression in mice experiencing unpredictable chronic mild stress.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Valsartan reverses depressive/anxiety-like behavior and induces hippocampal neurogenesis and expression of BDNF protein in unpredictable chronic mild stress mice

Sign up to use Study Snapshot

References

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

Chronic stress-induced depression is primarily caused by disturbances in microglial functioning, suggesting that microglia stimulators could serve as fast-acting anti-depressants in some stress-related conditions.

Recurrent depression, cardiovascular disease, and diabetes among middle-aged and older adult women.

Recurrent major depression disorder (MDD) significantly increases the risk of cardiovascular disease and diabetes in middle- and older-aged women, while single episode MDD does not.

Coping strategies, depressive symptoms and quality of life in hypertensive patients: Mediational and prospective relations

Depressive symptoms mediate the relationship between coping strategies and quality of life in hypertensive patients, while instrumental coping strategies play a long-term role in managing hypertension.

Neurogenesis-Independent Antidepressant-Like Effects on Behavior and Stress Axis Response of a Dual Orexin Receptor Antagonist in a Rodent Model of Depression

A dual orexin receptor antagonist, almorexant, effectively reduces depressive symptoms and restores stress-related HPA axis dysfunction in mice, without affecting neurogenesis.

Anxiolytic-like effect of losartan injected into amygdala of the acutely stressed rats

Losartan injections into the amygdala show anxiolytic-like effects in both non-stress and stressed conditions, suggesting potential as a new treatment for anxiety disorders.

Citations