Vanadium-catalyzed hydration of 2-cyanopyrazine to pyrazinamide with unique substrate specificity.

doi:10.1002/asia.202300741

Paper

Vanadium-catalyzed hydration of 2-cyanopyrazine to pyrazinamide with unique substrate specificity.

Published Sep 27, 2023 · Zhongxu Guo, Zhongtian Du, Yanbin Zhao

Chemistry, an Asian journal

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Abstract

Pyrazinamide is an important medicine used for the treatment of tuberculosis(TB). The preparation of pyrazinamide via catalytic hydration of 2-cyanopyrazine is of great economic interest with high atomic economy. Heterogeneous non-precious transition metal-catalyzed hydration of nitriles under neutral reaction conditions would be rather attractive. Herein vanadium-nitrogen-carbon materials were fabricated and employed for selective hydration of nitriles using water as both the solvent and reactant. 2-Cyanopyrazine could be smoothly converted into to pyrazinamide with unique substrate specificity. Additives with different N and O atoms could significantly affect hydration of 2-cyanopyrazine due to competitive adsorption/coordination in the reaction system. This work provides a new approach for non-precious metal catalyzed hydration of nitriles.

Study Snapshot

Vanadium-catalyzed hydration of 2-cyanopyrazine to pyrazinamide efficiently converts nitriles into valuable medicine for treating tuberculosis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Vanadium-catalyzed hydration of 2-cyanopyrazine to pyrazinamide with unique substrate specificity.

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