Paper
Visible-Light-Induced Difluoroalkylation of 1-(Allyloxy)-2-(1-arylvinyl)benzenes and 1-(1-Arylvinyl)-2-(vinyloxy)benzenes: Synthesis of Bis-Difluoroalkylated Benzoxepines and 2H-Chromenes.
Published Aug 2, 2022 · N. Zhou, Ziqin Xia, Kaimo Kuang
Organic letters
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Abstract
A novel visible-light-mediated difluoroalkylation of 1-(allyloxy)-2-(1-arylvinyl)benzenes and 1-(1-arylvinyl)-2-(vinyloxy)benzenes for the synthesis of bis-difluoroalkylated benzoxepines and 2H-chromenes is developed. This method features mild reaction conditions, good regioselectivity, a wide substrate scope, good functional-group compatibility, and late-stage modification. Preliminary mechanistic studies reveal that the generation of the CF2CO2Et radical is more prone to reaction with the double bond of the aryl group.
Visible-light-mediated difluoroalkylation of 1-(allyloxy)-2-(1-arylvinyl)benzenes allows for the synthesis of bis-difluoroalkylated benzoxepines and 2H-chromenes with mild reaction conditions
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