Vitamin B12 deficiency
Published 2017 ·
Nature Reviews Disease Primers
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Abstract
TRANSCOBALAMIN Autoimmune destruction of parietal cells and the consequent absence of intrinsic factor causes the classic manifestation of B12 deficiency — pernicious anaemia Vitamin B12 (B12) — also known as cobalamin — has an important role as a cofactor in many cellular processes, including DNA synthesis and methylation, and mitochondrial metabolism. Deficiency is associated with various symptoms, of which the haematological (mainly anaemia) and neurological (such as sensory and motor disturbances, ataxia and psychiatric disorders) manifestations are the most characteristic.
Study Snapshot
Key takeawayVitamin B12 deficiency can cause anaemia and neurological symptoms, with autoimmune destruction of parietal cells being the classic manifestation.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.