Paper
Vitamin E: critical review of its current use in cosmetic and clinical dermatology.
Published Mar 21, 2006 · DOI · J. Thiele, S. N. Hsieh, S. Ekanayake-Mudiyanselage
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
147
Citations
4
Influential Citations
Abstract
BACKGROUND AND OBJECTIVE The lipophilic antioxidant vitamin E has been used for more than 50 years in clinical and experimental dermatology. However, although a large number of case reports were published, there is still a lack of controlled clinical studies providing a rationale for clinical indications and dosage. In contrast, advances in basic research on the physiology, mechanism of action, penetration, bioconversion, and photoprotection of vitamin E in human skin have led to the development of numerous new formulations for use in cosmetics and skin care products. RESULTS This article reviews the basic mechanisms and possible cosmetical and clinical implications of the recent advances in cutaneous vitamin E research. Experimental evidence suggests that topical and oral vitamin E has anticarcinogenic, photoprotective, and skin barrier-stabilizing properties. CONCLUSION Although its current use is largely limited to cosmetics, controlled clinical studies for indications such as atopic dermatitis or prevention of photocarcinogenesis are needed to evaluate the clinical benefit of vitamin E.
Vitamin E has potential clinical benefits for treating atopic dermatitis and photocarcinogenesis, but controlled clinical studies are needed for more definitive conclusions.
Full text analysis coming soon...