In Vitro Antimycobacterial Activity of 5-Chloropyrazinamide

doi:10.1128/AAC.42.2.462

Paper

In Vitro Antimycobacterial Activity of 5-Chloropyrazinamide

Published Feb 1, 1998 · M. Cynamon, R. J. Speirs, J. Welch

Antimicrobial Agents and Chemotherapy

Q1 SJR score

74

Citations

2

Influential Citations

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Abstract

ABSTRACT 5-Chloropyrazinamide and 5-chloropyrazinoic acid were evaluated for in vitro activity against Mycobacterium tuberculosis,Mycobacterium bovis, and several nontuberculous mycobacteria by a broth dilution method. 5-Chloropyrazinamide was more active than pyrazinamide against all organisms tested. It is likely that this agent has a different mechanism of action than pyrazinamide.

In Vitro Study

Highly Cited

Study Snapshot

5-Chloropyrazinamide shows greater in vitro antimycobacterial activity than pyrazinamide, suggesting a different mechanism of action.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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In Vitro Antimycobacterial Activity of 5-Chloropyrazinamide

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