: Dinitrosyl complexes of ferrum with thiosulfate or reduced glutathione were found to inhibit completely aggregation of human thrombocytes, suspended in artificial protein-free medium. The inhibitory effect appears to occur as a result of activating action of nitrogen oxide derived from the complexes and affecting the thrombocyte guanylate cyclase.

Dinitrosyl complexes of ferrum with thiosulfate or reduced glutathione effectively inhibit platelet aggregation by activating nitrogen oxide and affecting thrombocyte guanylate cyclase.

Paper

[Low molecular weight and protein dinitrosyl complexes of non-heme iron as inhibitors of platelet aggregation].

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