Whole-cell yeast-mediated preparation of (R)-2-chloro-1-(3-nitrophenyl)ethanol as a synthetic precursor for (R)-phenylephrine

doi:10.1016/J.MOLCATB.2013.07.021

Paper

DOI: 10.1016/J.MOLCATB.2013.07.021

Whole-cell yeast-mediated preparation of (R)-2-chloro-1-(3-nitrophenyl)ethanol as a synthetic precursor for (R)-phenylephrine

Published Dec 15, 2013 · Daisuke Tokoshima, Kengo Hanaya, M. Shoji

Journal of Molecular Catalysis B-enzymatic

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Abstract

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Study Snapshot

Whole-cell yeast-mediated production of (R)-2-chloro-1-(3-nitrophenyl)ethanol provides a synthetic precursor for (R)-phenylephrine, a selective 1-adrenergic receptor agonist, with 99.2% efficiency.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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