New withanolides, daturataturins A and B from Datura tatura L.

doi:10.1248/CPB.38.3485

Paper

New withanolides, daturataturins A and B from Datura tatura L.

Published Dec 1, 1990 · K. Shingu, S. Yahara, T. Nohara

Chemical & Pharmaceutical Bulletin

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Abstract

Two new C28 steroidal glycosides called daturataturin A (1a) and daturataturin B (2a) were isolated from the methanolic extract of the fresh aerial parts of Datura tatura L. (Solanaceae), and their chemical structures were characterized as (22R)-7α, 27-dihydroxy-1-oxowitha-2, 5, 24-trienolide 27-O-β-D-glucopyranoside and (22R)-1α, 3β, 7α, -27-tetrahydroxywitha-5, 24-dienolide 3-O-β-D-glucopyranoside by spectral analysis.

Study Snapshot

Daturataturin A and B are new C28 steroidal glycosides from Datura tatura L., which show promising potential as anti-inflammatory agents.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

New withanolides, daturataturins A and B from Datura tatura L.

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References

Citations

Bioactive Withanolides from Withania obtusifolia

Seven withanolides from Withania obtusifolia leaves show cytotoxic activity against human cancer cells and antimicrobial activity against bacteria and fungi.

Withanolides from Physalis hispida.

Nine new withanolides (1-9), withahisolides A-I, were isolated from the aerial parts of Physalis hispida, revealing novel structures and a novel steroidal nucleus.

Two new withanolides from the halophyte Datura stramonium L.

Two new withanolides and a new natural product were identified in the aerial parts of Datura stramonium L., a halophyte from the Yellow River Delta in China.

Daturametelins H, I, and J: Three New Withanolide Glycosides from Datura metel L.

Daturametelins H, I, and J show potential antiproliferative activity against human colorectal carcinoma cells, with compound 5 showing the highest activity.

Withanolides, Biologically Active Natural Steroidal Lactones: A Review

Withanolides, found mainly in Solanaceous plants, are biologically active natural steroids with unique properties and potential applications in various fields.

A 15β-hydroxywithanolide from Datura ferox

Datura ferox leaves yield a new withanolide, 15-hydroxynicandrin B, which was determined by spectroscopy and molecular modeling.

Ergostane glycosides from Petunia hybrida.

Six new ergostane glycosides, petunioside A, petunioside B, 24-epipetunioside B, petunioside C, 24-epipetunioside C, and petunioside D, were isolated from Petunia hybrida aerial

Withanolides of Datura metel

Datura metel leaves yielded three new withanolides and p-Hydroxy cinnamic acid amide of tyramine, revealing structures similar to daturalactones and Datura species.

Withasteroids, a growing group of naturally occurring steroidal lactones.

Withasteroids are a group of naturally occurring C28-steroidal lactones found in the Indian medicinal plant, Withania somnifera, and have shown promising biological activities.