Adverse effects of unnecessary lisinopril use

Pro Research Analysisby

Searched over 200M research papers

Analyzed relevant papers

Adverse Effects of Unnecessary Lisinopril Use

Autoimmune and Dermatological Reactions: Pemphigus Vulgaris

Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, has been linked to rare but serious autoimmune skin conditions such as pemphigus vulgaris. This blistering disease affects the skin and mucous membranes and, while previously associated with other ACE inhibitors, has now been reported in connection with lisinopril use as well .

Gastrointestinal Complications: Enteropathy and Pancreatitis

Unnecessary use of lisinopril can lead to significant gastrointestinal side effects. Cases have shown that lisinopril may cause sprue-like enteropathy, presenting as chronic diarrhea, weight loss, and intestinal damage. Symptoms typically resolve after discontinuing the drug, highlighting the importance of recognizing this rare but reversible adverse effect . Additionally, lisinopril has been associated with severe, sometimes fatal, necrotizing pancreatitis, a life-threatening inflammation of the pancreas .

Visceral Angioedema: Abdominal Pain and Misdiagnosis

Lisinopril can cause visceral (intestinal) angioedema, a condition where swelling occurs in the intestines. This leads to symptoms like abdominal pain and diarrhea, which are often mistaken for other gastrointestinal disorders. The diagnosis is frequently missed, resulting in unnecessary medical interventions. Discontinuing lisinopril typically resolves the symptoms 36.

Neurological Effects: Nightmares

There are reports of lisinopril causing nightmares, a less common but notable side effect. Nightmares resolved when the medication was stopped and returned when it was restarted, suggesting a probable link between lisinopril and this adverse effect .

Conclusion

Unnecessary use of lisinopril exposes patients to a range of potential adverse effects, including autoimmune skin diseases, gastrointestinal complications like enteropathy and pancreatitis, visceral angioedema, and neurological symptoms such as nightmares. Recognizing these risks is crucial to avoid unnecessary harm, especially when lisinopril is not medically indicated 123456.

Sources and full results

Most relevant research papers on this topic

Oroesophageal Pemphigus vulgaris Secondary to Lisinopril Use: A New Side Effect

Lisinopril use may cause oroesophageal pemphigus vulgaris, a new and potentially serious side effect.

Case ReportRigorous Journal

2021·

2citations

·U. Tariq et al.

S2793 Sprue-Like Enteropathy Secondary to Lisinopril Use

Lisinopril use can cause sprue-like enteropathy, which resolves when the medication is stopped.

Case Report

2020·

1citation

·J. Cheong et al.

ACE inhibitor induced visceral angioedema: an elusive diagnosis

ACE inhibitors can cause intestinal angioedema, a non-specific presentation and chronology, leading to missed diagnosis and unnecessary interventions.

Case Report

2020·

1citation

·Metlapalli Venkata Sravanthi et al.

Lisinopril‐Induced Nightmares

Lisinopril may cause nightmares, but the exact mechanism responsible for this adverse effect remains unclear.

Case Report

2010·

0citations

·Megan M. Brockman et al.

A Fatal Case of Lisinopril-Induced Acute Necrotizing Pancreatitis

Lisinopril use can cause fatal cases of severe necrotizing pancreatitis, highlighting the need for caution when treating hypertension with ACE-I inhibitors.

Case Report

2023·

2citations

·Omar M Masarweh et al.

Isolated intestinal type angioedema due to ACE‐inhibitor therapy

Lisinopril can cause rare cases of intestinal angioedema, requiring early diagnosis and prompt treatment to avoid delays and unnecessary procedures.

Case Report

2017·

19citations

·Stephen R. Palmquist et al.

Underreported Risk of Lisinopril-Induced Angioedema in a Veteran Population

The risk of lisinopril-induced angioedema in veterans increases to 1.6% due to underreporting, requiring providers to consider LIA when prescribing lisinopril.

Observational Study

2021·

1citation

·Whitley J Whitehead et al.

A study of the prevalence of significant increases in serum creatinine following angiotension-converting enzyme inhibitor administration

End-stage renal disease is an unlikely outcome among patients prescribed lisinopril, and is likely associated with other events.

Observational StudyRigorous Journal

2005·

9citations

·ML Thorp et al.

Lisinopril-Induced Alopecia: A Case Report

Lisinopril-induced alopecia can be successfully resolved by discontinuing the drug and switching to angiotensin receptor blocker losartan potassium, highlighting the need for clinicians to be aware of potential drug reactions.

Case Report

2017·

9citations

·Vivek K. Kataria et al.

Lisinopril‐associated bullous pemphigoid in an elderly woman: a case report of a rare adverse drug reaction

Lisinopril-induced bullous pemphigoid is a rare and dose-response variant of this adverse reaction, affecting elderly women with hypertension, hypothyroidism, and diabetes.

Case ReportVery Rigorous Journal

2018·

11citations

·Rami A Ballout et al.

Try another search

black hole universe hypothesis

calcium channel antagonist

side effects of ace inhibitors

natural remedies for medication side effects

pharmaceutical identification of pills with imprint P10

record low temperatures around the world