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Some studies suggest Aloe vera is safe and effective for various uses, including anti-hyperglycemic, anti-hypercholesterolemic, anti-tumor, and as a functional food, while other studies indicate potential toxicity, including intestinal irritation, carcinogenicity, and liver damage.
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Aloe vera is a popular herbal remedy used for various health benefits, including anti-inflammatory, anti-hyperglycemic, and anti-hypercholesterolemic effects. However, its safety profile has been a subject of debate, with studies reporting both beneficial and adverse effects. This synthesis aims to evaluate the safety of Aloe vera based on data from multiple research papers.
General Safety in Short-Term Use:
Potential Carcinogenic Effects:
Hepatotoxicity Concerns:
No Observed Adverse Effect Level (NOAEL):
Safety in Specific Preparations:
The safety of Aloe vera largely depends on the form and duration of its use. Short-term use of Aloe vera gel and certain purified extracts appears to be safe, with no significant adverse effects reported. However, long-term use of whole-leaf Aloe vera extracts may pose carcinogenic risks, and there are documented cases of aloe-induced hepatotoxicity. Therefore, while Aloe vera can be considered safe for short-term use in specific preparations, caution is advised for long-term consumption, especially of whole-leaf extracts.
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