Amlodipine 10 mg uses

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Amlodipine 10 mg for Hypertension Management

Amlodipine 10 mg is widely used to treat high blood pressure (hypertension). It is a calcium channel blocker that helps lower blood pressure by relaxing blood vessels, making it easier for the heart to pump blood. This dose is especially effective for patients whose blood pressure is not controlled with lower doses, such as 5 mg daily. Studies show that amlodipine 10 mg provides a greater reduction in both systolic and diastolic blood pressure compared to 5 mg, and is well tolerated by most patients, including those with diabetes or chronic kidney disease, without worsening kidney or blood sugar function 14. It is also effective in older adults, helping to prevent strokes and heart attacks .

Amlodipine 10 mg for Stable Angina and Heart Health

Amlodipine 10 mg is also used to treat stable angina (chest pain due to heart disease). In patients with stable angina, this dose improves exercise tolerance, delays the onset of chest pain during physical activity, and enhances the function of the left ventricle (the heart’s main pumping chamber). These benefits are more pronounced at the 10 mg dose compared to lower doses, making it a good option for patients who need better control of their angina symptoms .

Additional Uses of Amlodipine 10 mg

Besides hypertension and angina, amlodipine is sometimes used for other conditions such as arrhythmias, subarachnoid hemorrhage, migraine, and Raynaud's disease, due to its effects on blood vessels and minimal impact on heart rate .

Side Effects and Tolerability of Amlodipine 10 mg

The most common side effect of amlodipine 10 mg is peripheral edema (swelling of the legs or ankles), which occurs more frequently at this higher dose compared to lower doses. Other possible side effects include palpitations, dizziness, and flushing 15. However, most patients tolerate the medication well, and the risk of headache is actually lower with amlodipine compared to placebo, especially at lower doses . The 10 mg dose is generally safe, but mild peripheral edema may occur in a small percentage of patients 45.

Conclusion

Amlodipine 10 mg is an effective and well-tolerated option for managing high blood pressure and stable angina, especially in patients who do not respond to lower doses. It offers sustained blood pressure control, cardiovascular protection, and improved exercise tolerance, with manageable side effects for most patients 124.

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Most relevant research papers on this topic

Amlodipine in the current management of hypertension

Amlodipine effectively lowers blood pressure and protects against stroke and myocardial infarction, with long-lasting effects and cost-saving potential compared to usual care.

Literature Review

2023·

35citations

·Ji-Guang Wang et al.

Amlodipine in patients with stable angina pectoris treated with nitrates and beta-blockers. The influence on exercise tolerance, systolic and diastolic functions of the left ventricle.

Amlodipine significantly improves exercise tolerance and left ventricle function in patients with stable angina pectoris, with 10 mg dose being most effective and well-tolerated.

RCT

1992·

7citations

·J. Meluzin et al.

An interesting case of refractory hypotension and noncardiogenic pulmonary edema after amlodipine overdose

A 34-year-old male patient successfully treated refractory hypotension and noncardiogenic pulmonary edema after ingesting 90 tablets of amlodipine 10 mg.

Case Report

2024·

0citations

·I. Alur

The Phase III, double-blind, parallel-group controlled study of amlodipine 10 mg once daily in Japanese patients with essential hypertension who insufficiently responded to amlodipine 5 mg once daily

Amlodipine 10 mg once daily is superior to amlodipine 5 mg once daily, safe, well-tolerated, and useful for patients with essential hypertension who insufficiently respond to the former.

Rigorous Journal

2009·

11citations

·T. Fujiwara et al.

Peripheral edema and headache associated with amlodipine treatment: a meta-analysis of randomized, placebo-controlled trials.

Amlodipine treatment increases the risk of peripheral edema, but up to one-third of edema cases may not be caused by the drug, and headaches are reduced when using low/medium doses.

Meta-AnalysisVery Rigorous Journal

2019·

12citations

·Davor Vukadinović et al.

Pharmacokinetics and bioequivalence of fixed-dose combination of candesartan cilexetil/amlodipine besylate (16/10 mg) versus coadministration of individual formulations in healthy subjects

The fixed-dose combination of candesartan (16 mg) and amlodipine (10 mg) is bioequivalent to single agent administration and well-tolerated in healthy subjects.

RCTVery Rigorous Journal

2020·

1citation

·H. Lee et al.

Biowaiver Study On Three Generic Brands of Amlodipine 10mg Tablets Marketed In Sudan

Three generic brands of amlodipine 10mg tablets (B, C, and D) in Sudan are bioequivalent to the innovator brand (A) and meet WHO criteria for Biowaiver, indicating their interchangeability.

2022·

0citations

·Rowida Abbadi W. Mohammed et al.

Design and stability study of an oral solution of amlodipine besylate for pediatric patients.

A pediatric oral solution of amlodipine besylate, suitable for use in children, has been developed and validated, with a stable shelf-life of 12 months at 4°C and in-use stability of 18 weeks.

2016·

22citations

·A. V. D. Vossen et al.

EFFECTIVENESS PROFILE OF AMLODIPINE AND LISINOPRIL IN HYPERTENSION OUTPATIENTS AT PRATAMA CLINIC SIDOARJO

Both amlodipine 10 mg and lisinopril 10 mg effectively lower blood pressure in hypertension patients at the Sidoarjo Pratama Clinic.

2023·

0citations

·Andri Priyoherianto et al.

Comparison of the Effect of Morning Versus Night Amlodipine Administration on Blood Pressure Reduction in Primary Hypertensive Patients

Amlodipine therapy effectively reduces blood pressure in primary hypertensive patients, with no significant difference in blood pressure reduction between morning and night administration.

2023·

0citations

·Eziah Ika Lubada et al.

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