Amlodipine and alcohol

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Amlodipine and Alcohol: Interactions and Effects

Introduction to Amlodipine and Alcohol Interaction

Amlodipine, a calcium channel blocker, is commonly prescribed for hypertension and other cardiovascular conditions. Alcohol consumption, on the other hand, is prevalent in many populations and can have significant health impacts, particularly on the liver and cardiovascular system. Understanding the interaction between amlodipine and alcohol is crucial for patients who consume alcohol and are on this medication.

Effects of Amlodipine on Alcohol-Induced Liver Damage

Research has explored the potential hepatoprotective effects of amlodipine in the context of alcohol-induced liver damage. A study involving patients with severe acute alcoholic hepatitis found that while amlodipine was well-tolerated, it did not significantly improve survival rates compared to a placebo . This suggests that while amlodipine may be safe for use in patients with alcoholic liver disease, it does not offer a therapeutic benefit in terms of survival.

Amlodipine and Alcohol Consumption in Animal Models

Animal studies have provided insights into the effects of amlodipine on alcohol-induced damage. In rats, high doses of amlodipine were found to have protective effects against alcohol-induced aortic wall injuries, although these benefits were not observed at lower doses . However, another study indicated that amlodipine did not prevent alcohol-induced myocardial injuries, highlighting a potential limitation in its protective capabilities .

Pharmacokinetic Interactions Between Amlodipine and Alcohol

The pharmacokinetic interaction between amlodipine and alcohol has been investigated in human volunteers. The study found that while alcohol consumption led to variations in pharmacokinetic parameters, the overall bioavailability of amlodipine remained within acceptable limits . This suggests that moderate alcohol consumption may not significantly alter the effectiveness of amlodipine, although further research is needed to understand the impact of higher alcohol intake.

Behavioral and Toxicological Effects

In behavioral studies, amlodipine did not significantly alter the reinforcing effects of alcohol in rats, except at high doses, which were associated with behavioral toxicity . Additionally, a case report highlighted the potential for fatal overdose when amlodipine is combined with alcohol, emphasizing the need for caution in patients with a history of alcohol abuse .

Conclusion

The interaction between amlodipine and alcohol is complex and multifaceted. While amlodipine is generally well-tolerated and does not significantly alter its pharmacokinetics when consumed with moderate alcohol, its protective effects against alcohol-induced damage are limited and dose-dependent. Patients on amlodipine should be cautious with alcohol consumption, particularly at higher levels, to avoid potential adverse effects. Further research is needed to fully understand the implications of this interaction and to provide clear guidelines for patients.

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Most relevant research papers on this topic

Randomised controlled double-blind trial of the calcium channel antagonist amlodipine in the treatment of acute alcoholic hepatitis.

Calcium channel blockers are well-tolerated and have few side effects in advanced alcoholic liver disease, but their effectiveness in treating acute alcoholic hepatitis remains unclear.

RCT

1998·

36citations

·G. Bird et al.

Amlodipine, a Calcium Channel Inhibitor, and Cocaine and Ethanol's Reinforcing Effects

Amlodipine does not reliably modify cocaine's reinforcing effects, while isradipine effectively reduces both cocaine's and alcohol's reinforcing effects.

Non-RCTAnimal Study

1999·

6citations

·L. Gardell et al.

Perindopril, atenolol, and amlodipine prevent aortic ultrastructural changes in rats exposed to ethanol.

High doses of perindopril, atenolol, and amlodipine may have protective effects against heavy chronic alcohol consumption-induced aortic wall injury in rats.

Rigorous Journal

2008·

8citations

·M. Yokuşoǧlu et al.

The prevention of myocardial ultrastructural changes by perindopril, atenolol and amlodipine in chronic alcohol administered rats.

Perindopril and atenolol have protective effects on myocardial injury caused by heavy chronic alcohol consumption in rats, while amlodipine does not.

Non-RCTAnimal Study

2006·

9citations

·C. Saǧ et al.

Pharmacokinetic interaction between alcohol and two of the commonly prescribed anti-hypertensive drugs-amlodipine and nebivolol

Two standard drinks of alcohol have limited effect on the pharmacokinetics of Amlodipine and Nebivolol, with bioavailability remaining comparable.

Non-RCT

2017·

1citation

·G. Gunasekaran et al.

Amlodipine, an anti‐hypertensive drug, alleviates non‐alcoholic fatty liver disease by modulating gut microbiota

Amlodipine effectively alleviates non-alcoholic fatty liver disease and hypertension by modulating gut microbiota, a potential therapeutic strategy for metabolic syndrome.

Non-RCTVery Rigorous Journal

2021·

33citations

·Yang Li et al.

Alcohol-induced reductions in cardiac protein synthesis in vivo are not ameliorated by treatment with the dihydropyridine calcium channel blocker amlodipine.

Ethanol reduces cardiac protein synthesis in vivo, but calcium channel blockers do not prevent these effects, suggesting ethanol affects protein synthesis independently of altered calcium entry.

Non-RCTAnimal Study

2000·

4citations

·V. Patel et al.

A fatal case of amlodipine poisoning.

A fatal overdose of amlodipine, a calcium channel blocker, was caused by an accumulation due to the long half-life of this drug.

Case Report

2003·

31citations

·S. Johansen et al.

Ethanol enhances the hemodynamic effects of felodipine.

Ethanol can enhance felodipine's hemodynamic effects, leading to clinically relevant adverse effects, such as postural lightheadedness.

RCTHighly Cited

1989·

189citations

·David G. Bailey et al.

Amlodipine overdose

Amlodipine overdose can cause prolonged hemodynamic effects and may lead to pulmonary edema, requiring aggressive decontamination therapy and extended monitoring.

Case Report

1997·

4citations

·E. Stanek et al.

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