Amlodipine and benazepril
Pro Research Analysisby 
Searched over 200M research papers
Efficacy and Safety of Amlodipine and Benazepril Combination Therapy for Hypertension
Introduction to Amlodipine and Benazepril Combination Therapy
Amlodipine, a calcium channel blocker, and benazepril, an angiotensin-converting enzyme (ACE) inhibitor, are commonly used in combination to treat hypertension. This combination therapy has been extensively studied for its efficacy in reducing blood pressure and cardiovascular events, as well as its safety profile.
Cardiovascular Outcomes with Amlodipine and Benazepril
Superior Reduction in Cardiovascular Events
Research has consistently shown that the combination of benazepril and amlodipine is more effective in reducing cardiovascular events compared to other combinations. In a large randomized trial involving 11,506 high-risk patients, the combination of benazepril and amlodipine significantly reduced the rate of cardiovascular events by 19.6% compared to benazepril and hydrochlorothiazide . This combination also showed a 25% reduction in the hazard ratio for cardiovascular death, myocardial infarction, and stroke in patients with coronary artery disease .
Renal Outcomes and Chronic Kidney Disease
The combination of benazepril and amlodipine has also been shown to slow the progression of chronic kidney disease more effectively than benazepril and hydrochlorothiazide. In the ACCOMPLISH trial, the progression of chronic kidney disease was significantly lower in patients treated with benazepril and amlodipine (2.0%) compared to those treated with benazepril and hydrochlorothiazide (3.7%) .
Blood Pressure Control and Safety Profile
Efficacy in Blood Pressure Reduction
Studies have demonstrated that the combination of benazepril and amlodipine provides superior blood pressure control compared to monotherapy or other combinations. For instance, a study comparing benazepril and amlodipine to high-dose calcium antagonist monotherapy found that the combination therapy was equally effective in lowering diastolic pressure but with fewer adverse effects such as edema . Another study confirmed that low-dose amlodipine (2.5 mg) combined with benazepril (10 mg) was more effective in reducing blood pressure than either drug alone .
Safety and Tolerability
The combination of benazepril and amlodipine is generally well-tolerated. Adverse events such as peripheral edema are less frequent with the combination therapy compared to high-dose monotherapy with calcium antagonists . Additionally, the combination therapy has a similar incidence of adverse experiences as monotherapy or placebo, with a lower incidence of edema compared to amlodipine alone 57.
Pharmacokinetic Interactions
Studies have shown that there are no significant pharmacokinetic interactions between benazepril and amlodipine, indicating that the combination does not alter the absorption or metabolism of either drug . This supports the safety and efficacy of using these drugs together in clinical practice.
Conclusion
The combination of amlodipine and benazepril is highly effective in reducing blood pressure and cardiovascular events in patients with hypertension. It also offers a favorable safety profile with fewer adverse effects compared to high-dose monotherapy. Given its superior efficacy in both cardiovascular and renal outcomes, this combination therapy should be considered a preferred treatment option for patients with hypertension, especially those at high risk for cardiovascular events.
Sources and full results
Most relevant research papers on this topic