Amlodipine max dose

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Maximum Dose of Amlodipine: Insights from Research

Introduction to Amlodipine and Its Usage in Hypertension

Amlodipine is a widely used calcium channel blocker prescribed for the treatment of hypertension and angina. It is known for its efficacy in reducing blood pressure and its relatively favorable side effect profile. Understanding the maximum effective and safe dose of amlodipine is crucial for optimizing patient outcomes.

Maximum Dose of Amlodipine

Clinical Studies on Amlodipine Dosage

Several studies have investigated the dosage range of amlodipine, typically ranging from 2.5 mg to 10 mg daily. In a double-blind, placebo-controlled study, amlodipine was administered in doses ranging from 2.5 mg to 10 mg daily over an 8-week period. The study found that a 10 mg daily dose was effective in significantly reducing blood pressure without major adverse effects, although slight ankle edema was reported in some patients at this dose .

Comparison with Combination Therapies

A study comparing the efficacy of increasing the dose of amlodipine to 10 mg versus combining 5 mg of amlodipine with 5 mg of bisoprolol found that the combination therapy resulted in a more significant reduction in diastolic blood pressure. This suggests that while 10 mg of amlodipine is effective, combination therapies might offer additional benefits in certain patient populations .

Pharmacokinetics and Bioavailability

Pharmacokinetic studies have shown that amlodipine has a dose-proportional increase in plasma concentration with doses of 2.5 mg, 5 mg, and 10 mg. The half-life of amlodipine increases slightly with higher doses, indicating a prolonged effect, which supports the once-daily dosing regimen . Additionally, bioequivalence studies have confirmed that a 10 mg dose of amlodipine is well absorbed and maintains consistent plasma levels .

Efficacy in Elderly Patients

In elderly hypertensive patients, amlodipine at doses up to 10 mg daily was found to be effective in significantly reducing both systolic and diastolic blood pressures over a 14-week period. The study highlighted that elderly patients might experience a more pronounced blood pressure reduction compared to younger patients, possibly due to differences in drug clearance .

Safety and Tolerability

The safety profile of amlodipine at the maximum dose of 10 mg daily has been well-documented. Common side effects include headache and slight ankle edema, but these are generally mild and manageable. No significant changes in heart rate or electrocardiogram readings were observed, indicating a good safety margin for the drug 610.

Conclusion

The maximum recommended dose of amlodipine for the treatment of hypertension is 10 mg daily. This dosage has been shown to be effective in significantly reducing blood pressure with a favorable safety profile. However, in some cases, combination therapies may offer additional benefits. Clinicians should consider individual patient characteristics, such as age and comorbid conditions, when determining the optimal dosing strategy.

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Most relevant research papers on this topic

Once daily amlodipine in the treatment of mild to moderate hypertension.

Once-daily amlodipine effectively reduces blood pressure in patients with mild to moderate hypertension, with no significant effects on heart rate or heart rate variability.

RCT

1987·

44citations

·J. Webster et al.

An anchored simulated treatment comparison of uptitration of amlodipine compared with a low-dose combination treatment with amlodipine 5 mg/bisoprolol 5 mg for patients with hypertension suboptimally controlled by amlodipine 5 mg monotherapy

The low-dose combination of amlodipine 5 mg and bisoprolol 5 mg effectively reduces diastolic blood pressure in hypertensive patients, while no significant difference is seen in systolic blood pressure.

2022·

2citations

·C. Foch et al.

Bioequivalence of levamlodipine besylate tablets in healthy Chinese subjects: a single-dose and two-period crossover randomized study

Levamlodipine besylate tablets show bioequivalence with amlodipine tablets at single doses of 5 mg and 10 mg in healthy Chinese subjects.

RCTRigorous Journal

2020·

0citations

·Xin Li et al.

Amlodipine in elderly hypertensive patients: pharmacokinetics and pharmacodynamics.

Amlodipine effectively lowers systolic blood pressure in elderly hypertensive patients, with similar results to young patients, but clearance is decreased and elimination half-life is prolonged.

Non-RCT

1988·

45citations

·Darrell R. Abernethy et al.

Amlodipine Pharmacokinetics in Healthy Volunteers

Amlodipine effectively lowers blood pressure when given once daily, with headache being the most common side effect, and its long half-life and gradual absorption minimize side effects.

RCT

1988·

61citations

·Dennis M. Williams et al.

Amlodipine: a double-blind evaluation of the dose-response relationship in mild to moderate hypertension.

Amlodipine effectively reduces blood pressures with once-daily dosing, with 2.5 mg being the minimum effective dose, and is well-tolerated in patients with mild to moderate hypertension.

RCT

1988·

25citations

·Frick Mh et al.

Pharmacokinetics and bioequivalence evaluation of two formulations of 10-mg amlodipine besylate: an open-label, single-dose, randomized, two-way crossover study in healthy Chinese male volunteers.

The newly developed dispersible tablet formulation of amlodipine besylate shows bioequivalence with an established branded formulation in healthy Chinese male volunteers.

RCT

2009·

34citations

·Yun Liu et al.

Pharmacokinetic comparison of 2 fixed-dose combination tablets of amlodipine and valsartan in healthy male Korean volunteers: a randomized, open-label, 2-period, single-dose, crossover study.

The newly developed FDC tablet of amlodipine and valsartan did not significantly differ from the conventional FDC tablet in healthy Korean male subjects, with both formulations well-tolerated and no serious adverse events observed.

RCT

2013·

13citations

·Yukyung Kim et al.

Comparisons of the pharmacokinetics and tolerability of fixed-dose combinations of amlodipine besylate/losartan and amlodipine camsylate/losartan in healthy subjects: a randomized, open-label, single-dose, two-period, two-sequence crossover study

An FDC of 6.94 mg amlodipine besylate/5 mg losartan potassium is similar to an FDC of 5 mg amlodipine camsylate/5 mg losartan potassium in pharmacokinetics and tolerability in healthy male subjects.

RCTRigorous Journal

2016·

11citations

·Yoonjung Choi et al.

The pharmacokinetics of amlodipine in healthy volunteers after single intravenous and oral doses and after 14 repeated oral doses given once daily.

Amlodipine has a 36-hour half-life after intravenous administration and a 45-hour half-life after repeated oral administration, with steady state plasma concentration achieved after seven doses.

Non-RCTHighly Cited

1986·

228citations

·J. Faulkner et al.

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