Amlodipine maximum dosage
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Amlodipine Maximum Dosage in Hypertension and Heart Disease
Maximum Recommended Dosage of Amlodipine for Hypertension
Clinical studies have shown that amlodipine is effective in reducing blood pressure at doses ranging from 2.5 mg to 10 mg once daily. The maximum recommended daily dose for most patients with hypertension is 10 mg, as higher doses have not been shown to provide additional benefit and may increase the risk of side effects. In a double-blind trial, patients received up to 10 mg daily, and this was considered the highest effective and well-tolerated dose for blood pressure control . Another study comparing dose escalation found that increasing amlodipine from 5 mg to 10 mg daily provided further blood pressure reduction in patients not controlled on 5 mg, confirming 10 mg as the maximum standard dose .
Maximum Dosage in Coronary Artery Disease
In patients with coronary artery disease, intravenous amlodipine was studied at cumulative doses up to 20 mg, but the minimum effective intravenous dose was found to be 10 mg. This suggests that, even in this population, 10 mg is the typical maximum daily dose for clinical use .
Fixed-Dose Combinations and Maximum Dosage
Fixed-dose combination tablets containing amlodipine are available in strengths up to 10 mg, often combined with other antihypertensive agents such as olmesartan or valsartan. Pharmacokinetic studies confirm that amlodipine 10 mg in combination tablets is bioequivalent to 10 mg given alone, supporting the use of 10 mg as the maximum dose in combination therapies as well 46.
Safety and Tolerability at Maximum Dosage
Across studies, amlodipine at doses up to 10 mg daily was generally well tolerated, with side effects being mild to moderate in intensity. There were no significant effects on heart rate, electrocardiogram, or body weight at this dose .
Conclusion
The maximum recommended dosage of amlodipine for adults is 10 mg once daily, whether used alone or in combination with other medications for hypertension or coronary artery disease. This dose is effective, well tolerated, and supported by multiple clinical studies 12346.
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