Amlodipine vs lisinopril safety
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Safety Profile of Amlodipine vs Lisinopril in Hypertension Treatment
Comparative Safety in Monotherapy: Amlodipine vs Lisinopril
Large-scale studies show that both amlodipine (a calcium channel blocker) and lisinopril (an ACE inhibitor) are generally safe and effective for treating hypertension, with no significant differences in major outcomes like heart attack or overall mortality between the two drugs. However, some differences in side effects and specific risks have been observed. For example, lisinopril is associated with a higher risk of stroke in Black patients and women, as well as higher rates of gastrointestinal bleeding and angioedema compared to amlodipine. On the other hand, lisinopril is linked to a lower risk of heart failure than amlodipine. Blood pressure control is similar in non-Black patients, but amlodipine may provide better control in Black patients, which could explain some of the differences in outcomes .
Safety and Tolerability of Combination Therapy
Multiple studies have evaluated the safety of combining amlodipine and lisinopril, either as a fixed-dose combination or as separate agents. These studies consistently report that the combination is well tolerated, with most adverse effects being mild and rarely leading to discontinuation. Common minor side effects include lower leg edema (more common with amlodipine) and dry cough (more common with lisinopril), but serious adverse events are rare. The combination is considered safe for long-term use in patients with moderate to severe hypertension, and is also effective in patients with additional cardiovascular risks 15678910.
Safety in Special Populations and Cost Considerations
In elderly patients with hypertension, both amlodipine and lisinopril have similar safety profiles and effectiveness in reducing left ventricular mass and improving heart function. However, lisinopril may be more cost-effective, which can be an important consideration in some healthcare settings . Studies in high-risk patients, including those with coronary heart disease or high cholesterol, also show that the combination of lisinopril and amlodipine is safe and effective, with most adverse events being mild 710.
Bioequivalence and Tolerability in Different Populations
Bioequivalence studies in healthy subjects confirm that fixed-dose combinations of lisinopril and amlodipine are well tolerated, with no severe adverse events reported. The safety profile remains consistent under both fasting and fed conditions, although a high-fat meal may slightly reduce the absorption of lisinopril without causing safety concerns .
Conclusion
Amlodipine and lisinopril are both safe options for treating hypertension, with some differences in side effect profiles. Amlodipine may be preferred in Black patients due to better blood pressure control and lower stroke risk, while lisinopril may be favored for patients at risk of heart failure. Combination therapy with both drugs is well tolerated and effective, with most side effects being mild and rarely leading to treatment discontinuation. Overall, both drugs and their combination offer safe choices for blood pressure management in a wide range of patients 12345678+2 MORE.
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