Anti inflammatory supplements for gut
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Anti-Inflammatory Supplements for Gut Health
Introduction to Gut Inflammation and Supplements
Gut inflammation is a common issue linked to various diseases, including inflammatory bowel disease (IBD) and obesity-related conditions. Recent research has focused on dietary supplements that can modulate gut microbiota and reduce inflammation. This article synthesizes findings from multiple studies on the effectiveness of different anti-inflammatory supplements for gut health.
Wheat Germ: Enhancing Beneficial Bacteria and Reducing Inflammation
Wheat germ (WG) supplementation has shown promising results in promoting an anti-inflammatory gut environment. In a study involving mice fed a high-fat, high-sucrose diet, WG increased the beneficial bacterial family Lactobacillaceae by fourfold and elevated fecal short-chain fatty acids, which are crucial for gut health. Additionally, WG upregulated the expression of anti-inflammatory cytokines and antimicrobial peptides while reducing pro-inflammatory cytokines in the serum1. These findings suggest that WG can significantly modulate gut microbiota and reduce systemic inflammation.
Smilax China L. Flavonoid: Regulating the Gut-Liver Axis
Smilax china L. flavonoid (SCF) has been traditionally used to treat inflammatory disorders. Recent research indicates that SCF can alleviate inflammation by modulating the gut-liver axis. In mice, SCF supplementation reduced body weight gain, serum levels of pro-inflammatory cytokines, and lipopolysaccharides (LPS). It also increased the abundance of gut barrier-protective species like Akkermansia spp. and decreased harmful bacteria such as Desulfovibrionaceae2. These changes contribute to a reduced inflammatory response and improved gut health.
Vitamin D, Fish Oil, and Resveratrol: Mitigating IBD
Dietary supplements like vitamin D, fish oil, and resveratrol have been studied for their potential to mitigate inflammatory bowel disease (IBD). These supplements can positively affect the gut microbiome, helping to restore balance and reduce intestinal inflammation. They represent promising adjuvant treatments for limiting inflammation in IBD patients3.
Fructooligosaccharides (FOS): Enhancing Gut Immune Response
Fructooligosaccharides (FOS) are prebiotics that can modulate gut microbiota and enhance the immune response. Studies have shown that FOS increases beneficial bacteria like bifidobacteria and short-chain fatty acids, stimulates IgA secretion, and decreases pro-inflammatory cytokines4. These effects contribute to an improved gut immune system and reduced inflammation.
Sesamol: Protecting Gut Barrier Integrity
Sesamol, a lignan extract, has demonstrated potent anti-inflammatory properties. In a study on colitis-induced mice, sesamol supplementation improved gut barrier integrity by enhancing the expression of tight junction proteins and increasing short-chain fatty acids. It also modulated the gut microbiome, increasing beneficial bacteria and reducing inflammation via the NF-κB signaling pathway5.
Grape Seed Proanthocyanidin Extract (GSPE): Modulating Gut Microbiota
Grape seed proanthocyanidin extract (GSPE) has been found to reduce inflammation and adiposity in high-fat diet-induced obesity. GSPE supplementation decreased plasma levels of inflammatory factors and modulated gut microbiota composition, increasing beneficial bacteria like Clostridium XIVa and Roseburia. These changes were linked to improved metabolic health and reduced inflammation6.
Probiotics, Prebiotics, and Synbiotics: Effective for IBD
Probiotics, prebiotics, and synbiotics have shown effectiveness in treating IBD, particularly ulcerative colitis. These supplements can induce and maintain remission, reduce disease activity, and increase beneficial bacteria like Bifidobacteria in the gut. Synbiotics, which combine probiotics and prebiotics, are particularly effective7.
Flavonoids from Passiflora Foetida: Anti-Inflammatory and Microbiota Modulation
Flavonoids extracted from Passiflora foetida fruits have demonstrated significant anti-inflammatory effects. These flavonoids reduce the production of pro-inflammatory cytokines and modulate gut microbiota by promoting beneficial bacteria and short-chain fatty acid production. This dual action makes them a promising natural anti-inflammatory agent8.
Microalga Lobosphaera Incisa: Alleviating Gut Inflammation
The microalga Lobosphaera incisa, rich in omega-6 LC-PUFA dihomo-γ-linolenic acid (DGLA), has shown potential in alleviating gut inflammation. In a zebrafish model of IBD, dietary inclusion of this microalga reduced gut injury and modulated immune gene expression and gut microbiota composition, suggesting its beneficial effects are not limited to DGLA alone9.
Caffeic Acid: Reducing Colonic Inflammation
Caffeic acid (CA), a phenolic acid found in coffee, has been shown to alleviate colonic inflammation. In a study on colitis-induced mice, CA supplementation improved gut health by reducing pro-inflammatory cytokines, enhancing antioxidant capacity, and modulating gut microbiota composition. These effects highlight CA's potential as a protective agent against gut inflammation10.
Conclusion
Various dietary supplements, including wheat germ, Smilax china L. flavonoid, vitamin D, fish oil, resveratrol, fructooligosaccharides, sesamol, grape seed proanthocyanidin extract, probiotics, prebiotics, synbiotics, flavonoids from Passiflora foetida, microalga Lobosphaera incisa, and caffeic acid, have shown significant potential in reducing gut inflammation and improving gut health. These supplements work through different mechanisms, such as modulating gut microbiota, enhancing gut barrier integrity, and reducing pro-inflammatory cytokines, making them promising options for managing gut-related inflammatory conditions.
Sources and full results
Most relevant research papers on this topic
Wheat Germ Supplementation Increases Lactobacillaceae and Promotes an Anti-inflammatory Gut Milieu in C57BL/6 Mice Fed a High-Fat, High-Sucrose Diet.
Wheat germ supplementation increases beneficial gut bacteria and reduces inflammation in mice fed a high-fat, high-sucrose diet, potentially preventing diet-induced comorbidities.
RCT
Animal Study
Very Rigorous JournalSmilax china L. flavonoid alleviates HFHS-induced inflammation by regulating the gut-liver axis in mice.
Smilax china L. flavonoid effectively inhibits high-fat/high-sucrose-induced inflammation in mice by suppressing pro-inflammatory bacteria and increasing gut barrier protective species Akkermansia spp.
RCTAnimal Study
Rigorous JournalDietary Supplementation with Vitamin D, Fish Oil or Resveratrol Modulates the Gut Microbiome in Inflammatory Bowel Disease
Dietary supplements with vitamin D, fish oil, and resveratrol may help modulate the gut microbiome and reduce intestinal inflammation in inflammatory bowel disease.
Fructooligosaccharides on inflammation, immunomodulation, oxidative stress, and gut immune response: a systematic review.
FOS supplementation is positively associated with an anti-inflammatory and antioxidant effect, enhancing the gut immune system, potentially benefiting human health.
Systematic ReviewSesamol supplementation attenuates DSS-induced colitis via mediating gut barrier integrity, inflammatory responses, and reshaping gut microbiome.
Sesamol supplementation effectively reduces DSS-induced colitis by promoting gut microecology, restoring gut barrier integrity, and inhibiting inflammation.
Non-RCTAnimal StudyGrape seed proanthocyanidin extract ameliorates inflammation and adiposity by modulating gut microbiota in high-fat diet mice.
Grape seed proanthocyanidin extract reduces inflammation and adiposity in high-fat diet mice by modulating gut microbiota composition, offering potential for prevention and treatment of metabolic disorders.
Non-RCTAnimal StudyVery Rigorous Journal
Highly CitedClinical effects and gut microbiota changes of using probiotics, prebiotics or synbiotics in inflammatory bowel disease: a systematic review and meta-analysis
Probiotics, prebiotics, and synbiotics can induce remission and reduce disease activity in inflammatory bowel disease patients, with synbiotics being more effective.
Meta-AnalysisRigorous JournalHighly CitedAnti-Inflammatory and Gut Microbiota Modulation Potentials of Flavonoids Extracted from Passiflora foetida Fruits
Passiflora foetida fruit's flavonoid-rich fraction shows anti-inflammatory and gut microbiota modulation potentials, making it a potential natural anti-inflammatory agent or supplement.
In Vitro StudyDietary Application of the Microalga Lobosphaera incisa P127 Reduces Severity of Intestinal Inflammation, Modulates Gut-Associated Gene Expression and Microbiome in the Zebrafish Model of IBD.
Dietary inclusion of L. incisa P127 microalga significantly reduces gut inflammation and modulates gut-associated gene expression and microbiome in a zebrafish model of IBD.
Non-RCTAnimal StudyCaffeic Acid Supplement Alleviates Colonic Inflammation and Oxidative Stress Potentially Through Improved Gut Microbiota Community in Mice
Caffeic acid supplementation effectively alleviates colonic inflammation and oxidative stress in mice by improving defense against oxidative stress and inflammatory response.
Non-RCTAnimal StudyHighly Cited