Aortic atherosclerosis
Searched over 200M research papers for "aortic atherosclerosis"
Summary
10 papers analyzed
These studies suggest that aortic atherosclerosis involves complex immunologic mechanisms, distinct risk factors, and potential autoimmune reactions, with inflammation and plaque formation being key features.
Not a yes or no question
To use the Consensus Meter, try asking a simple yes or no question
Research summarized with Copilot
Beta20 papers analyzed
Aortic Atherosclerosis: Insights and Implications
Introduction to Aortic Atherosclerosis
Aortic atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids, cholesterol, and other substances in the aorta's inner walls. This condition leads to the formation of plaques, which can restrict blood flow and cause serious cardiovascular events. The disease is driven by a complex interplay of genetic, environmental, and immunological factors.
Immune Cell Diversity in Aortic Atherosclerosis
Recent studies have highlighted the significant role of immune cells in the development and progression of aortic atherosclerosis. Single-cell RNA sequencing and mass cytometry have revealed a diverse array of leukocyte populations in atherosclerotic aortas, including macrophages, T-cells, and monocytes. These cells exhibit distinct phenotypic and transcriptional profiles, with specific pathways related to lipid metabolism, proliferation, and cytokine secretion being confined to particular leukocyte clusters. This diversity underscores the complexity of the immune response in atherosclerosis and suggests potential targets for therapeutic intervention.
Aortic Aneurysms and Atherosclerosis: Distinct Yet Related
Aortic aneurysms and atherosclerosis often coexist, but recent evidence suggests they may be more distinct than previously thought. While atherosclerosis is a significant risk factor for aneurysms, the two conditions have different risk profiles. For instance, diabetes, hypercholesterolemia, and obesity are more strongly associated with atherosclerosis, whereas smoking, gender, and ethnicity are higher risk factors for aneurysms. This distinction is crucial for developing targeted prevention and treatment strategies for each condition.
Aortic Valve Sclerosis and Atherosclerosis
Aortic valve sclerosis (AVSc) is increasingly recognized as an atherosclerosis-like process. Studies have shown a significant association between AVSc and nonalcoholic fatty liver disease (NAFLD), suggesting that metabolic syndrome features contribute to both conditions. The prevalence of AVSc is notably higher in patients with NAFLD, indicating a potential link between metabolic dysfunction and aortic valve abnormalities. This relationship highlights the importance of managing metabolic risk factors to prevent both aortic valve sclerosis and atherosclerosis.
Gender Differences in Aortic Atherosclerosis
Research using murine models has demonstrated significant gender differences in the extent of aortic atherosclerosis. Male mice, particularly those deficient in LDL receptors or apolipoprotein E, tend to develop more extensive aortic lesions compared to females. This finding suggests that gender-specific factors may influence the development and progression of atherosclerosis, which could have implications for personalized treatment approaches.
Aortic Atherosclerosis and Embolic Events
Aortic plaques can lead to serious embolic events, including strokes and peripheral thromboembolism. These plaques can give rise to thromboemboli, which occlude larger arteries, and atheroemboli, which block smaller vessels. The management of aortic embolism primarily involves general atherosclerosis management strategies, as there are no specific therapies for aortic embolism itself. This highlights the need for effective prevention and control of atherosclerosis to mitigate the risk of embolic events.
Autoimmune Reactions in Aortic Atherosclerosis
Emerging evidence suggests that aortic atherosclerosis may involve autoimmune reactions. Studies have found increased infiltration of immune cells, such as plasma cells and lymphocytes, and elevated levels of interleukin-17 (IL-17) in the aortic walls of individuals with atherosclerosis. These findings indicate that autoimmune mechanisms may contribute to the inflammation and progression of atherosclerosis . Understanding these mechanisms could open new avenues for therapeutic interventions targeting autoimmune pathways.
Conclusion
Aortic atherosclerosis is a multifaceted disease influenced by immune responses, genetic factors, and metabolic conditions. The interplay between these factors determines the development and progression of the disease, as well as its association with other conditions like aortic aneurysms and valve sclerosis. Continued research into the underlying mechanisms and risk factors is essential for developing targeted prevention and treatment strategies to combat this pervasive cardiovascular disease.
Sources and full results
Most relevant research papers on this topic
