Searched over 200M research papers for "aps-1 autoantibodies"
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These studies suggest that APS-1 autoantibodies target various organ-specific and steroidogenic enzymes, aiding in diagnosis and understanding of disease mechanisms, with specific autoantibodies linked to conditions like hypoparathyroidism, pulmonary disease, and autoimmune hepatitis.
20 papers analyzed
Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare monogenic autoimmune disorder characterized by the presence of multiple autoantibodies targeting various organs and tissues. Understanding the specific autoantibodies involved in APS-1 is crucial for diagnosing and managing the disease, as well as for gaining insights into its pathogenesis.
Identification of Novel Autoantigens:
Autoantibodies Against Steroidogenic Enzymes:
Autoantibodies Against Aromatic L-amino Acid Decarboxylase (AADC):
Autoantibodies Against Cytochrome P450 Enzymes:
Autoantibodies Against Type I Interferons:
Autoantibodies Against Potassium Channel Regulatory Protein (KCNRG):
Autoantibodies Against NALP5:
APS-1 is characterized by a diverse array of autoantibodies targeting various organs and tissues. Key autoantibodies include those against novel autoantigens, steroidogenic enzymes, AADC, cytochrome P450 enzymes, type I interferons, KCNRG, and NALP5. These autoantibodies not only aid in diagnosing APS-1 but also provide insights into the disease's pathogenesis and potential therapeutic targets.
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