Ashwagandha estrogen

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Ashwagandha and Estrogen: Insights from Recent Research

Introduction to Ashwagandha and Hormonal Effects

Ashwagandha (Withania somnifera) is a well-known herb in Ayurvedic medicine, reputed for its ability to enhance vitality, muscle strength, and overall health. Recent studies have explored its impact on various hormones, including estrogen, in both humans and animal models.

Ashwagandha's Impact on Estrogen in Aging Males

A study focusing on aging, overweight males investigated the effects of ashwagandha on several steroid hormones, including estradiol, a form of estrogen. Participants were administered ashwagandha extract over a period of 16 weeks. The results indicated that while ashwagandha significantly increased levels of DHEA-S and testosterone, there were no significant changes in estradiol levels between the ashwagandha and placebo groups . This suggests that ashwagandha may not have a notable impact on estrogen levels in this demographic.

Ashwagandha and Estrogen in Diabetic and Non-Diabetic Male Rats

Another study examined the effects of dietary ashwagandha root powder on sex hormones in diabetic and non-diabetic male rats. The research aimed to determine the impact on estrogen, among other hormones. The findings revealed that ashwagandha did not significantly alter estrogen levels in either diabetic or non-diabetic rats . This aligns with the human study, indicating a consistent lack of significant effect on estrogen levels across different models.

Conclusion

Current research suggests that ashwagandha does not significantly affect estrogen levels in both human males and male rats, regardless of diabetic status. While it shows promise in increasing other hormones like DHEA-S and testosterone, its impact on estrogen remains minimal. Further studies with larger sample sizes and diverse populations are needed to confirm these findings and explore any potential long-term effects.

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Most relevant research papers on this topic

A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males

Ashwagandha intake for 8 weeks increased levels of DHEA-S and testosterone in overweight men, but did not significantly affect cortisol, estradiol, fatigue, vigor, or sexual well-being.

RCTRigorous Journal

2019·

55citations

·Adrian L. Lopresti et al.

Effect of dietary intake Ashwagandha roots powder on the levels of sex hormones in the diabetic and non-diabetic male rats.

Ashwagandha roots powder can prevent diabetes-induced hormonal dysfunction by inhibiting hyperglycemia and hyperlipidemia, while only lowering FSH serum levels in intact animals.

Non-RCTAnimal Study

2012·

14citations

·Nehal M. Belal et al.

Iron chelation and antioxidant properties of Withania somnifera (Ashwagandha) restore fertility in men and women

Ashwagandha restores fertility in men and women by improving testicular and ovarian functions, making it a safer and more cost-effective alternative to synthetic drugs.

2023·

0citations

·H. Tuli et al.

Ashwagandha in brain disorders: A review of recent developments.

Ashwagandha shows potential as a neuroprotective agent in various brain disorders, but further study is needed to confirm its mechanistic pathways and promote it as a promising drug candidate.

Systematic Review

2020·

63citations

·Sultan Zahiruddin et al.

Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study

Ashwagandha root extract significantly improves sperm count, semen volume, and motility in males with oligospermia, potentially reducing infertility.

RCTRigorous JournalHighly Cited

2013·

134citations

·V. Ambiye et al.

Adaptogenic and Immunomodulatory Activity of Ashwagandha Root Extract: An Experimental Study in an Equine Model

Ashwagandha root extract has potent hemopoietic, antioxidant, adaptogenic, and immune-stimulant properties, effectively reducing stress-related health issues in horses.

RCTAnimal Study

2020·

28citations

·G. Priyanka et al.

Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review

Ashwagandha shows potential as a valuable natural remedy for various health concerns, including neuroprotective, sedative, adaptogenic, anti-inflammatory, cardioprotective, and anti-diabetic properties.

Literature Review

2023·

66citations

·Paulina Mikulska et al.

Safety of Ashwagandha Root Extract: A Randomized, Placebo-Controlled, Study in Healthy Volunteers.

Ashwagandha root extract consumption for 8 weeks was safe in both males and females, with no reported adverse events.

RCT

2020·

46citations

·N. Verma et al.

Keeping abreast about Ashwagandha in breast cancer.

Ashwagandha shows potential as a chemotherapeutic agent against various types of breast cancer, with potential benefits for ER/PR positive and triple-negative breast cancers.

Systematic Review

2020·

11citations

·R. Vashi et al.

Effect of standardized root extract of ashwagandha (Withania somnifera) on well‐being and sexual performance in adult males: A randomized controlled trial

Ashwagandha root extract improves sexual health and well-being in adult males, as demonstrated in a randomized controlled trial.

RCT

2022·

15citations

·Sanjaya Chauhan et al.

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