Atorvastatin tablet identification
Pro Research Analysisby 
Searched over 200M research papers
Atorvastatin Tablet Identification Methods
Analytical Techniques for Atorvastatin Identification
Several analytical methods are used to identify atorvastatin in tablet formulations. High-performance liquid chromatography (HPLC) is a widely used technique for both the identification and quantification of atorvastatin and its impurities in bulk drugs and tablets. HPLC methods provide good resolution for atorvastatin and its related substances, including impurities such as desfluoro-atorvastatin and diastereomer-atorvastatin, even in the presence of excipients commonly found in tablets Misbahuddin2013Ertürk2003.
Fourier Transform Infrared (FT-IR) spectroscopy and FT-Raman spectroscopy are also effective for identifying atorvastatin in tablets. FT-Raman spectroscopy, in particular, has demonstrated a lower detection limit and high accuracy for quantitative determination, even when different polymorphic forms of atorvastatin are present in the formulation Skorda2008Al-Nasi2024.
Ultraviolet (UV) spectrophotometry is another method used for content uniformity and identification, especially in quality control settings. This method is simple and effective for routine analysis, ensuring that the correct amount of active pharmaceutical ingredient is present in each tablet .
Quality Control and Consistency in Atorvastatin Tablets
Quality control tests such as weight variation, hardness, friability, disintegration, and dissolution are essential for confirming the identity and consistency of atorvastatin tablets. Studies from various markets, including Saudi Arabia, Iraq, Indonesia, and Yemen, have shown that both innovator and generic brands of atorvastatin tablets generally meet pharmacopoeial standards for these parameters AlMuhsin2022Al-Nasi2024Alkufi2023+2 MORE. These tests ensure that the tablets contain the appropriate amount of atorvastatin and have consistent physical properties, which are critical for therapeutic effectiveness.
Detection and Quantification of Impurities
HPLC is also the primary method for detecting and quantifying impurities in atorvastatin tablets. Studies have found that the total amount of impurities in commercial atorvastatin tablets is typically less than 1%, which is within acceptable limits for pharmaceutical products Misbahuddin2013Ertürk2003. The ability to identify and quantify impurities is important for ensuring the safety and efficacy of the medication.
Conclusion
Atorvastatin tablet identification relies on robust analytical techniques such as HPLC, FT-Raman, FT-IR, and UV spectrophotometry. These methods ensure accurate identification, quantification, and quality control of atorvastatin in tablet formulations. Consistent results across different brands and markets confirm that most atorvastatin tablets meet regulatory standards for identity, content, and quality, making them safe and effective for patient use Skorda2008AlMuhsin2022Al-Nasi2024+5 MORE.
Sources and full results
Most relevant research papers on this topic
Identification and quantitative determination of atorvastatin calcium polymorph in tablets using FT-Raman spectroscopy.
FT-Raman spectroscopy effectively identifies and quantifies atorvastatin calcium polymorphs in tablets, with a 1.25% error rate on commercial 40 mg strength tablets.
Quality assessment of different brands of atorvastatin tablets available in Riyadh, Saudi Arabia
All generic brands of atorvastatin tablets in Saudi Arabia meet pharmacopoeia's consistency checks, making them suitable for interchangeable use.
A Comparative Study between Legally Imported and Smuggled Brands of Atenolol and Atorvastatin Drugs Marketed in Aden, Yemen
Legally imported and smuggled Atenolol and Atorvastatin drugs in Aden, Yemen, meet most quality control specifications, but variations exist in some tests.
Quality Assessment of Brands and Generic in Atorvastatin Tablets Available in Iraq-thi-Qar
Atorvastatin tablets from both innovator and generic brands in Iraq are of high pharmaceutical grade, meeting all required tests, and can be used interchangeably based on their in vitro release characteristics.
Uniformity Test Tablets Of Atorvastatin on the Market Using Ultraviolet Spectrophotometer
Atorvastatin tablets in Indonesia meet the standard requirements for weight uniformity and content uniformity, with CV 5% and levels within 90.0 % - 110.0 % of the labeled amount.
DOI