Average weight loss with trulicity
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Trulicity (Dulaglutide) and Average Weight Loss: Key Findings
Weight Loss Outcomes with Trulicity in Clinical and Real-World Settings
Trulicity (dulaglutide) is a GLP-1 receptor agonist used primarily for type 2 diabetes, but it also offers weight loss benefits. Clinical trials and real-world studies consistently show that dulaglutide leads to moderate weight loss in adults with type 2 diabetes and obesity 236.
Average Weight Loss Results
In clinical trials, dulaglutide 1.5 mg once weekly has been associated with consistent reductions in body weight from baseline. While the exact average weight loss varies by study and patient population, the reductions are described as significant and durable, with benefits maintained for up to two years 23. In a real-world digital obesity program that included dulaglutide among other GLP-1 medications, patients achieved an average weight loss of 16.2% at 12 months and 17.2% at 24 months. For those without medication disruptions, weight loss was even higher, averaging 17% at 12 months and 18.6% at 24 months . However, these results reflect a mix of GLP-1 medications, not dulaglutide alone.
In a smaller study of patients with type 2 diabetes and obesity, dulaglutide 0.75 mg weekly led to a decrease in BMI of about 0.78 after 3 months and 1.16 after 6-9 months, indicating modest but meaningful weight loss . Case reports also highlight significant weight reduction in individuals with morbid obesity who had not succeeded with other methods .
Weight Loss Compared to Other GLP-1 Medications
While dulaglutide is effective for weight loss, some newer GLP-1 medications like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro) have shown even greater average weight loss in head-to-head comparisons and real-world usage trends 46. However, dulaglutide remains a valuable option, especially for those with type 2 diabetes 23.
Safety and Tolerability
Dulaglutide is generally well tolerated, with the most common side effects being gastrointestinal, such as nausea and diarrhea. The risk of hypoglycemia is low, making it a safe choice for many patients 235.
Conclusion
Trulicity (dulaglutide) leads to moderate, clinically meaningful weight loss in adults with type 2 diabetes and obesity, with average reductions maintained over time. While the exact average weight loss varies, studies report consistent benefits, especially when combined with lifestyle interventions. Dulaglutide is a safe and effective option, though some newer GLP-1 medications may offer greater weight loss for certain patients 12367.
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