B12 shot side effects

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Side Effects of B12 Shots: An Overview

Allergic Reactions to Cyanocobalamin Injections

One of the notable side effects of B12 shots, specifically those containing cyanocobalamin, is the potential for allergic reactions. In a documented case, a 63-year-old woman experienced redness, tenderness, and itching at the injection site following each cyanocobalamin injection. Additionally, oral ingestion of cyanocobalamin triggered similar reactions at previous injection sites. This patient also had positive patch test reactions to cobalt chloride and cyanocobalamin solutions, indicating a specific allergic sensitivity to these substances .

Side Effects from Proprietary Vitamin B12 Preparations

Another study investigated the side effects associated with a proprietary preparation of vitamin B12 derived from Streptomyces griseus fermentation liquors. This preparation was used extensively for treating pernicious anemia due to its effectiveness and low cost. The study aimed to determine whether the side effects were caused by the vitamin B12 itself or by contaminants in the preparation. The findings suggested that certain factors might predispose individuals to these side effects, although the exact cause was not definitively identified .

Conclusion

In summary, while B12 shots are essential for individuals with specific deficiencies, they can cause side effects, including allergic reactions and other adverse effects potentially linked to contaminants in the preparation. It is crucial for healthcare providers to be aware of these risks and monitor patients accordingly.

Sources and full results

Most relevant research papers on this topic

B12 Shots—Still Another Side of the Coin

Cyanocobalamin injections may cause allergic reactions, even when they are therapeutically needed, and their use should be based on a patient's specific needs and tolerance levels.

Case Report

1975·

0citations

·A. Fisher

Side-effects of a Preparation of Vitamin B12

Vitamin B12 injections from Streptomyces griseus fermentation liquors may cause side-effects, and factors like age and gender may predispose to their occurrence.

1952·

18citations

·P. Bedford

Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh

Vitamin B12 supplementation during pregnancy and lactation improves maternal, infant, and breast milk B12 status, but only improves H1N1 vaccine-specific responses in mothers.

RCTRigorous JournalHighly Cited

2016·

87citations

·T. Siddiqua et al.

A vitamin B12 conjugate of exendin‐4 improves glucose tolerance without associated nausea or hypophagia in rodents

The vitamin B12 conjugate of exendin-4 improves glucose tolerance without causing nausea or hypophagia in rodents, offering a potential treatment option for type 2 diabetes and obesity without side effects.

Rigorous Journal

2018·

32citations

·Elizabeth G. Mietlicki-Baase et al.

Type 1 hypersensitivity from vitamin B12 injection: a case report

Intramuscular cyanocobalamin injections for vitamin B12 deficiency can cause rare, life-threatening anaphylactic reactions, highlighting the need for vigilant healthcare providers.

Case Report

2022·

0citations

·E. M. Khatrawi et al.

Cyanocobalamin-induced anaphylactic reaction

Anaphylactic reactions to Vitamin B12 are a rare but serious side effect, and should be closely monitored during patient administration, especially when using the parenteral route.

Case Report

2023·

0citations

·Cyril Sajan et al.

Effects of metformin on vitamin B12 levels, including dose and duration of therapy: a narrative review

Long-term metformin therapy, especially at high doses, may increase the risk of vitamin B12 deficiency, requiring regular monitoring.

Systematic Review

2023·

0citations

·Agata Wójcik-Kula et al.

Vitamin B12 as a Treatment for Pain.

Vitamin B12 shows potential as an adjunctive or integrative treatment for pain conditions, with potential synergistic benefits when combined with other pain medications.

Systematic Review

2019·

39citations

·S. Buesing et al.

Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression

Vitamin B12 supplementation is likely ineffective for improving cognitive function and depressive symptoms in patients without advanced neurological disorders.

Meta-AnalysisVery Rigorous Journal

2021·

61citations

·Stefan Markun et al.

Is high vitamin B12 status a cause of lung cancer?

Vitamin B supplementation can have side effects for human health, including cancer risk. We aimed to elucidate the role of vitamin B12 in lung cancer etiology via direct measurements of pre‐diagnostic circulating vitamin B12 concentrations in a nested case–control study, complemented with a Mendelian randomization (MR) approach in an independent case–control sample. We used pre‐diagnostic biomarker data from 5183 case–control pairs nested within 20 prospective cohorts, and genetic data from 29,266 cases and 56,450 controls. Exposures included directly measured circulating vitamin B12 in pre‐diagnostic blood samples from the nested case–control study, and 8 single nucleotide polymorphisms associated with vitamin B12 concentrations in the MR study. Our main outcome of interest was increased risk for lung cancer, overall and by histological subtype, per increase in circulating vitamin B12 concentrations. We found circulating vitamin B12 to be positively associated with overall lung cancer risk in a dose response fashion (odds ratio for a doubling in B12 [ORlog2B12] = 1.15, 95% confidence interval (95%CI) = 1.06–1.25). The MR analysis based on 8 genetic variants also indicated that genetically determined higher vitamin B12 concentrations were positively associated with overall lung cancer risk (OR per 150 pmol/L standard deviation increase in B12 [ORSD] = 1.08, 95%CI = 1.00–1.16). Considering the consistency of these two independent and complementary analyses, these findings support the hypothesis that high vitamin B12 status increases the risk of lung cancer.

Observational StudyRigorous Journal

2019·

60citations

·A. Fanidi et al.

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