Benadryl withdrawal

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Benadryl Withdrawal: Understanding the Recurrence of Symptoms and Side Effects

Introduction to Benadryl and Its Uses

Benadryl, known chemically as β-dimethylaminoethyl benzhydryl ether hydrochloride, is widely used for its anti-histaminic properties in treating various allergic conditions. It has shown effectiveness in alleviating symptoms such as urticaria, pruritis, and other allergic dermatoses 14. However, its use is primarily palliative, meaning it provides temporary relief rather than a cure 14.

Recurrence of Symptoms Post-Withdrawal

Allergic Conditions

One of the significant challenges with Benadryl is the recurrence of symptoms upon withdrawal. Studies have consistently shown that symptoms return shortly after discontinuing the drug. This is particularly evident in patients with allergic conditions such as urticaria and pruritis, where the relief provided by Benadryl is temporary 14. The recurrence of symptoms underscores the need for ongoing management and investigation into the underlying allergic factors .

Asthma

In the context of asthma, the recurrence of symptoms post-withdrawal is also notable. Research indicates that while Benadryl can provide symptomatic relief for some asthmatic patients, the benefits are not sustained after the drug is stopped. This is especially true for patients whose asthma is complicated by respiratory infections or organic lung lesions . The temporary nature of relief highlights the necessity for comprehensive asthma management strategies beyond antihistamines .

Side Effects and Tolerance

Common Side Effects

Benadryl is associated with a range of side effects, which can limit its use. Common side effects include drowsiness, dizziness, dry mouth, and fatigue, occurring in a significant proportion of patients 134. These side effects are often unpredictable and can vary in severity among different individuals .

Development of Tolerance

Some patients may develop a tolerance to Benadryl, necessitating dosage adjustments. For instance, in cases of urticaria, initial relief may diminish over time, requiring either increased dosages or alternative treatments . This tolerance development further complicates the long-term management of allergic conditions with Benadryl.

Conclusion

Benadryl remains a valuable tool in the management of allergic symptoms, providing temporary relief for conditions such as urticaria, pruritis, and certain cases of asthma. However, the recurrence of symptoms upon withdrawal and the frequent side effects pose significant challenges. These issues highlight the importance of ongoing allergic investigations and the need for comprehensive treatment plans that address the underlying causes of allergic reactions.

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Most relevant research papers on this topic

beta-dimethylaminoethyl benzhydryl ether hydrochloride (benadryl); its use in allergic diseases.

Benadryl is a useful drug for treating allergic symptoms, but its effectiveness varies and side effects are common, making it useful for those able to tolerate it for symptom control during allergic investigations.

Observational Study

1946·

46citations

·S. J. Levin

The Journal of allergy

Tetany following removal of a parathyroid adenoma with bone disease; finally alleviated with calciferol.

Antistin effectively relieved nausea and vomiting in a patient receiving streptomycin treatment for bone disease.

Case Report

1949·

0citations

·N. Conway

British medical journal

Evaluation of dimethylaminoethyl benzhydryl ether hydrochloride (benadryl) in bronchial asthma.

Abstract 1.1. Benadryl was administered orally in dosages of 150 to 400 mg. daily to a group of thirty adult asthmatics who were resistant to all forms of the usual asthmatic remedies. 2.2. Seven or 23 per cent of the patients experienced symptomatic relief. Withdrawal of the drug was followed by recurrence of symptoms. 3.3. Benadryl was beneficial to those patients whose asthmatic symptoms were not due to acute upper respiratory infections or to demonstrable organic lesions in the lungs or heart. 4.4. Twenty-three or 77 per cent of the patients failed to obtain any relief whatsoever. All of them showed organic changes in the lungs or heart or an active sinus infection. 5.5. The drug was without immediate effect upon severe attacks of asthma, regardless of etiology. 6.6. Benadryl was found to be helpful when used in conjunction with known antiasthmatic drugs. 7.7. Side reactions such as drowsiness, dizziness, dry mouth and fatigue occurred in twenty-eight or 93 per cent of the patients.

Non-RCT

1947·

3citations

·A. Fuchset al.

The American journal of medicine

Experimental and clinical evaluation of synthetic anti-histaminic drugs.

Benadryl and pyribenzamine show promising anti-histaminic properties, but their effectiveness in treating allergic disorders varies and side effects limit their use.

1946·

7citations

·S. Friedlaender

The American journal of medicine

Unusual side reaction of hysteria from benadryl.

Increasing the dose of benadryl to 350 mg. daily can cause severe hysteria, which resolves within 48 hours when the drug is withdrawn.

Case Report

1947·

13citations

·L. Sternberg

The Journal of allergy

Biochemical studies on diphenhydramine (benadryl) distribution in tissues and urinary excretion.

Benadryl rapidly enters the body and rapidly affects symptoms, with a small amount remaining unaltered in urine.

1949·

25citations

·A. Glazkoet al.

The Journal of biological chemistry

Accidental benadryl poisoning: Report of a fatal case

Accidental ingestion of 474 mg. of Benadryl by a 2-year-old child resulted in cyanosis, convulsions, cardiorespiratory depression, hyperthermia, and death.

Case Report

1949·

28citations

·Joseph H. Daviset al.

The Journal of Pediatrics

Degradation of benadryl by tissue enzymes.

Tissue enzymes degrade Benadryl, resulting in a loss of its basic properties and small portion of the total administered dose in man.

1949·

14citations

·A. Glazkoet al.

The Journal of biological chemistry

Medication Withdrawal Trials in People Aged 65 Years and Older

Medication withdrawal for antihypertensive, benzodiazepine, and psychotropic agents in older people shows short-term effectiveness and minimal harm without significant increase in mortality.

Systematic ReviewHighly Cited

2008·

331citations

·Shoba Iyeret al.

Drugs & Aging

Treatment of acute benadryl (diphenhydramine hydrochloride) intoxication with severe central nervous system changes and recovery.

Acute benadryl intoxication can cause severe central nervous system changes and recovery, with gastric lavage, reduction of hyperthermia, control of convulsions with barbiturates, and endotracheal tube support being key to survival.

Case Report

1955·

11citations

·T. Reichelderferet al.

The Journal of pediatrics

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