Benadryl withdrawal symptoms

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Benadryl Withdrawal Symptoms

Introduction to Benadryl and Its Uses

Benadryl, a common antihistamine, is widely used to treat symptoms of allergies, hay fever, and the common cold. It is known for its effectiveness in alleviating symptoms such as itching, runny nose, and sneezing. However, like many medications, discontinuing Benadryl can lead to withdrawal symptoms in some individuals.

Common Withdrawal Symptoms of Benadryl

Withdrawal symptoms from Benadryl can vary in severity and type. The most commonly reported symptoms include nausea, vomiting, and psychological effects such as depression and confusion.

Nausea and Vomiting

One study highlighted a case where a patient experienced nausea and vomiting after discontinuing Benadryl. The patient, who was initially treated with Benadryl to manage nausea, began to vomit again after the medication was substituted with another drug. This suggests that withdrawal from Benadryl can lead to the reappearance of gastrointestinal symptoms such as nausea and vomiting .

Psychological Effects: Depression and Confusion

Psychological symptoms are also notable during Benadryl withdrawal. In one case, a patient who was taking a high dose of Benadryl for hay fever experienced severe depression and confusion. Upon increasing the dose, the patient developed severe hysteria. However, these symptoms resolved within forty-eight hours after the drug was completely withdrawn, indicating a direct link between Benadryl withdrawal and psychological disturbances .

Conclusion

Benadryl withdrawal can lead to a range of symptoms, primarily affecting the gastrointestinal system and mental health. Nausea, vomiting, depression, confusion, and even severe hysteria have been reported. These symptoms typically resolve after discontinuation of the drug, but the severity can vary based on the dosage and duration of use. It is important for individuals discontinuing Benadryl to be aware of these potential withdrawal symptoms and to consult healthcare professionals if they experience severe reactions.

Sources and full results

Most relevant research papers on this topic

Tetany following removal of a parathyroid adenoma with bone disease; finally alleviated with calciferol.

Antistin effectively relieved nausea and vomiting in a patient receiving streptomycin treatment for bone disease.

Case Report

1949·

0citations

·N. Conway

British medical journal

Unusual side reaction of hysteria from benadryl.

Increasing the dose of benadryl to 350 mg. daily can cause severe hysteria, which resolves within 48 hours when the drug is withdrawn.

Case Report

1947·

13citations

·L. Sternberg

The Journal of allergy·

DOI

Evaluation of dimethylaminoethyl benzhydryl ether hydrochloride (benadryl) in bronchial asthma.

Abstract 1.1. Benadryl was administered orally in dosages of 150 to 400 mg. daily to a group of thirty adult asthmatics who were resistant to all forms of the usual asthmatic remedies. 2.2. Seven or 23 per cent of the patients experienced symptomatic relief. Withdrawal of the drug was followed by recurrence of symptoms. 3.3. Benadryl was beneficial to those patients whose asthmatic symptoms were not due to acute upper respiratory infections or to demonstrable organic lesions in the lungs or heart. 4.4. Twenty-three or 77 per cent of the patients failed to obtain any relief whatsoever. All of them showed organic changes in the lungs or heart or an active sinus infection. 5.5. The drug was without immediate effect upon severe attacks of asthma, regardless of etiology. 6.6. Benadryl was found to be helpful when used in conjunction with known antiasthmatic drugs. 7.7. Side reactions such as drowsiness, dizziness, dry mouth and fatigue occurred in twenty-eight or 93 per cent of the patients.

Non-RCT

1947·

3citations

·A. Fuchs et al.

The American journal of medicine·

DOI

beta-dimethylaminoethyl benzhydryl ether hydrochloride (benadryl); its use in allergic diseases.

Benadryl is a useful drug for treating allergic symptoms, but its effectiveness varies and side effects are common, making it useful for those able to tolerate it for symptom control during allergic investigations.

Observational Study

1946·

47citations

·S. J. Levin

The Journal of allergy·

DOI

Withdrawal symptoms in children after long-term administration of sedatives and/or analgesics: a literature review. “Assessment remains troublesome”

Benzodiazepine and opioid withdrawal symptoms in children largely overlap, and a sensitive instrument for assessing these symptoms in PICU patients is needed.

Systematic ReviewRigorous JournalHighly Cited

2007·

114citations

·E. Ista et al.

Intensive Care Medicine·

DOI

Treatment of acute benadryl (diphenhydramine hydrochloride) intoxication with severe central nervous system changes and recovery.

Acute benadryl intoxication can cause severe central nervous system changes and recovery, with gastric lavage, reduction of hyperthermia, control of convulsions with barbiturates, and endotracheal tube support being key to survival.

Case Report

1955·

11citations

·T. Reichelderfer et al.

The Journal of pediatrics·

DOI

Withdrawal Symptoms after Selective Serotonin Reuptake Inhibitor Discontinuation: A Systematic Review

SSRIs can cause withdrawal symptoms when discontinue, and the term 'discontinuation syndrome' should be replaced with 'withdrawal syndrome' to better describe these vulnerabilities.

Systematic ReviewHighly Cited

2015·

377citations

·G. Fava et al.

Psychotherapy and Psychosomatics·

DOI

Overview: a comparison of withdrawal symptoms from different drug classes.

Withdrawal from drugs of dependence can cause mood disturbances, sleep disturbances, and various somatic symptoms, with nicotine withdrawal leading to heightened irritability and stimulant withdrawal potentially causing depression.

Highly Cited

1994·

118citations

·Robert West et al.

Addiction·

DOI

A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features

Caffeine withdrawal syndrome is well characterized and warrants inclusion as a disorder in the DSM and revision of diagnostic criteria in the ICD.

Systematic ReviewRigorous JournalHighly Cited

2004·

565citations

·L. M. Juliano et al.

Psychopharmacology·

DOI

Unusual reaction following benadryl administration.

Benadryl administration can cause unusual side effects, including drowsiness, dizziness, weakness, and nausea, and should be used cautiously in patients with known side effects.

Case Report

1947·

17citations

·J. Geiger et al.

Journal of the American Medical Association·

DOI

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