Benefits of nmn
Pro Research Analysisby 
Searched over 200M research papers
Consensus Meter
Benefits of Nicotinamide Mononucleotide (NMN)
Introduction to NMN and NAD+ Metabolism
Nicotinamide mononucleotide (NMN) is a precursor to nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme involved in numerous metabolic processes. NAD+ plays a significant role in energy metabolism, DNA repair, and cell survival, making NMN a molecule of interest for its potential therapeutic benefits .
Anti-Aging and Age-Related Disease Mitigation
Cellular and Metabolic Health
Research indicates that NMN supplementation can effectively increase NAD+ levels, which decline with age. This increase in NAD+ has been shown to mitigate various age-associated physiological declines. In mouse models, NMN administration improved energy metabolism, physical activity, insulin sensitivity, and plasma lipid profiles, while also ameliorating eye function and other age-related pathologies .
Vascular Health
NMN has demonstrated significant vasoprotective effects in aged mice by improving endothelium-dependent vasodilation and reducing oxidative stress. These benefits are linked to the restoration of a youthful vascular microRNA expression profile, suggesting potential anti-atherogenic and epigenetic rejuvenation effects.
Cognitive Function
NMN supplementation has also been shown to rescue cerebromicrovascular endothelial function and improve neurovascular coupling responses in aged mice. This improvement in cerebral blood flow was associated with enhanced cognitive function, including better spatial working memory and gait coordination.
Reproductive Health
Oocyte Quality and Female Fertility
Advanced maternal age is often associated with a decline in oocyte quality. NMN supplementation has been found to improve the quality of oocytes in aged mice by restoring NAD+ levels. This leads to increased ovulation, enhanced meiotic competency, and better fertilization ability, ultimately improving reproductive outcomes .
Cardioprotection
Ischemia-Reperfusion Injury
NMN has shown cardioprotective effects against ischemia-reperfusion (IR) injury. This protection is partly due to the stimulation of glycolysis, which enhances ATP synthesis during ischemia and acidosis during reperfusion. These effects are crucial for maintaining heart function under stress conditions .
Gut Health
Intestinal Homeostasis
Long-term NMN treatment has been found to modulate gut microbiota diversity and composition, increasing the abundance of beneficial bacteria and reducing harmful ones. This modulation is associated with improved intestinal barrier function, reduced mucosal permeability, and enhanced gut health.
Safety and Efficacy in Humans
A placebo-controlled, randomized, double-blind trial in healthy human subjects demonstrated that oral NMN supplementation is safe and effectively increases NAD+ levels in the blood without causing any adverse effects. This suggests that NMN is a practical strategy for boosting NAD+ levels in humans.
Conclusion
NMN supplementation offers a wide range of benefits, from anti-aging effects and improved metabolic health to enhanced cognitive and reproductive functions. Its ability to increase NAD+ levels and modulate various biological processes makes it a promising therapeutic agent for age-related diseases and overall health maintenance.
Sources and full results
Most relevant research papers on this topic