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Some studies suggest that a Mediterranean diet improves glycemic control and cardiovascular risk factors, while other studies highlight the benefits of ketogenic, low-glycemic index, and personalized postprandial-targeting diets for managing prediabetes.
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The Mediterranean diet has been extensively studied for its benefits in managing prediabetes. This diet emphasizes the consumption of fruits, vegetables, whole grains, legumes, nuts, and olive oil, while limiting red meat and processed foods. Research indicates that adherence to the Mediterranean diet significantly improves glycemic control, reduces body mass index (BMI), and lowers triglycerides and glycated hemoglobin (HbA1c) levels . A systematic review and meta-analysis found that the Mediterranean diet is associated with better glycemic control and cardiovascular risk factors compared to lower-fat diets, making it a suitable option for managing prediabetes.
A study comparing a well-formulated ketogenic diet (WFKD) and a Mediterranean-plus diet (Med-Plus) found that both diets improved HbA1c levels in individuals with prediabetes. However, the ketogenic diet led to a greater reduction in triglycerides but also increased LDL cholesterol levels, which could pose cardiovascular risks. The Mediterranean diet was found to be more sustainable and provided a balanced intake of nutrients, including fiber from legumes, fruits, and whole grains.
A low-glycemic index (GI) diet, which focuses on consuming foods that have a minimal impact on blood glucose levels, has shown promise in managing prediabetes. Combining a low-GI diet with regular exercise significantly reduced insulin resistance and postprandial hyperinsulinemia in obese, prediabetic individuals. This diet helps in maintaining stable blood glucose levels and improving overall metabolic health.
Recent advancements in personalized nutrition have highlighted the importance of individualized dietary interventions based on glycemic responses. A study using a machine learning algorithm to predict personalized postprandial glucose responses (PPGR) found that a personalized diet targeting PPGRs led to significant improvements in glycemic control compared to a standard Mediterranean diet. This approach underscores the variability in individual responses to the same foods and the potential benefits of tailored dietary plans.
The CORDIOPREV study explored the effects of a low-fat diet compared to a Mediterranean diet in patients with prediabetes. The study found that a low-fat diet was more beneficial in reducing the risk of developing type 2 diabetes, particularly in individuals with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). This suggests that a low-fat diet may be a viable option for certain subgroups of prediabetic patients.
An exploratory trial focusing on meal sequence and nutritional balance demonstrated that dietary instructions emphasizing the order of food consumption and balanced nutrition could effectively reduce body weight in prediabetic individuals. This approach, known as SMART Washoku®, helps individuals adhere to a healthier diet by structuring meals in a way that optimizes nutrient intake and glycemic control.
In summary, the Mediterranean diet stands out as a highly effective dietary pattern for managing prediabetes, offering significant improvements in glycemic control and cardiovascular health. The ketogenic diet also shows benefits but comes with potential risks related to elevated LDL cholesterol. Personalized nutrition and low-GI diets offer promising alternatives, particularly when combined with regular exercise. Lastly, low-fat diets and structured meal sequences can be beneficial for specific subgroups of prediabetic individuals. Tailoring dietary interventions to individual needs and responses is crucial for optimal management of prediabetes.
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