Bronchitis wheezing
Searched over 200M research papers for "bronchitis wheezing"
Summary
10 papers analyzed
These studies suggest that bronchiolitis in infancy is associated with an increased risk of wheezing and asthma in later life, while treatments like antibiotics and inhaled corticosteroids during the acute phase do not significantly prevent post-bronchiolitic wheezing.
Not a yes or no question
To use the Consensus Meter, try asking a simple yes or no question
Research summarized with Copilot
Beta20 papers analyzed
Bronchitis and Wheezing: Insights from Recent Research
Childhood Bronchitis and Long-Term Respiratory Outcomes
Childhood Wheezy Bronchitis and COPD Risk
Research indicates that childhood wheezy bronchitis is associated with an increased risk of developing chronic obstructive pulmonary disease (COPD) later in life. A long-term cohort study followed children from age 10-15 into their 60s and found that those with childhood wheezy bronchitis had a significantly higher risk of COPD compared to controls. This association was evident through reduced FEV1 (Forced Expiratory Volume in one second) by the fifth decade of life, although it was not linked to an accelerated decline in FEV1.
Bronchiolitis and Recurrent Wheezing
Severe Bronchiolitis and Wheezing in Early Childhood
Severe bronchiolitis in infancy has been linked to an increased risk of recurrent wheezing by age three. A study identified three distinct profiles of severe bronchiolitis, with one profile (characterized by a history of breathing problems and non-respiratory syncytial virus infections) showing a significantly higher risk of recurrent wheezing. This profile also had higher eosinophil counts and specific nasopharyngeal microbiota profiles.
Mild Bronchiolitis as a Predictor of Wheezing
Even mild bronchiolitis in infancy can be a predictor of wheezing later in childhood. A historical cohort study found that children who had bronchiolitis were significantly more likely to experience wheezing at ages 6-9 compared to those who did not have bronchiolitis. This association remained significant even after adjusting for factors like family history of allergies and passive smoking.
Meta-Analysis on Early Bronchiolitis and Asthma
A meta-analysis of studies involving over 292,000 participants confirmed that bronchiolitis before the age of two is associated with an increased risk of developing wheezing and asthma later in life. This association was consistent across different age groups, geographical regions, and study qualities.
Treatment Approaches and Their Efficacy
Antibiotics for Persistent Symptoms Post-Bronchiolitis
The use of antibiotics to treat persistent cough or wheeze following acute bronchiolitis has not shown significant benefits. A review of randomized controlled trials found no significant differences in persistent symptoms or rehospitalization rates between children treated with antibiotics and those given a placebo.
Azithromycin and Recurrent Wheezing
Azithromycin treatment during respiratory syncytial virus (RSV) bronchiolitis has shown some promise in reducing recurrent wheezing. A study found that azithromycin reduced IL-8 levels in nasal lavage fluid and prolonged the time to the third wheezing episode, suggesting a potential benefit in reducing respiratory morbidity over the subsequent year.
Inhaled Corticosteroids and Post-Bronchiolitic Wheezing
Inhaled corticosteroids administered during the acute phase of bronchiolitis do not appear to prevent post-bronchiolitic wheezing. A review of randomized controlled trials found no significant effect on wheezing prevention, hospital readmissions, or the use of corticosteroids or bronchodilators .
Special Considerations
Primary Immunodeficiencies and Recurrent Bronchiolitis
Primary immunodeficiencies, such as ADA deficiency, should be considered in infants with recurrent bronchiolitis and wheezing. These conditions can present with symptoms similar to common respiratory issues but require different management approaches.
Conclusion
The relationship between bronchitis, bronchiolitis, and wheezing is complex and multifaceted. Childhood wheezy bronchitis and severe bronchiolitis in infancy are significant predictors of long-term respiratory issues, including COPD and recurrent wheezing. While some treatments like azithromycin show potential benefits, others, such as antibiotics and inhaled corticosteroids, have not demonstrated significant efficacy in preventing post-bronchiolitic wheezing. Understanding these associations and treatment outcomes is crucial for managing and potentially mitigating long-term respiratory complications in affected individuals.
Sources and full results
Most relevant research papers on this topic
