Bupropion hair loss

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Bupropion and Hair Loss: An Overview

Introduction to Bupropion and Hair Loss

Bupropion is a commonly prescribed antidepressant known for its unique pharmacological profile, which includes acting as a norepinephrine-dopamine reuptake inhibitor. While it is effective for treating depression and aiding smoking cessation, concerns have been raised about its potential side effects, including hair loss.

Comparative Risk of Hair Loss with Antidepressants

A large retrospective cohort study examined the risk of hair loss associated with various antidepressants, including bupropion. The study analyzed data from over a million new users of different antidepressants between 2006 and 2014. The findings indicated that bupropion had a higher risk of hair loss compared to other antidepressants such as fluoxetine and paroxetine. Specifically, the hazard ratio (HR) for hair loss with bupropion was 1.46 compared to fluoxetine, suggesting a significantly increased risk .

Bupropion in Trichotillomania Treatment

Interestingly, bupropion has also been explored as a treatment option for trichotillomania, a condition characterized by compulsive hair pulling leading to noticeable hair loss. In a case report, a 23-year-old woman with fluoxetine-resistant trichotillomania showed significant improvement when treated with bupropion and cognitive behavioral therapy. This suggests that while bupropion may increase the risk of hair loss in some contexts, it could also be beneficial in treating certain conditions that involve hair loss .

Conclusion

In summary, while bupropion is associated with a higher risk of hair loss compared to other antidepressants, it also shows promise in treating conditions like trichotillomania. Patients and healthcare providers should weigh these risks and benefits when considering bupropion as a treatment option. Further research is needed to fully understand the mechanisms behind bupropion-induced hair loss and its potential therapeutic applications.

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Most relevant research papers on this topic

Risk of hair loss with different antidepressants: a comparative retrospective cohort study

Bupropion has the highest risk of hair loss compared to other antidepressants, with fluoxetine and paroxetine having the lowest risk.

Observational StudyRigorous Journal

2018·

5citations

·M. Etminan et al.

Bupropion for the treatment of fluoxetine non-responsive trichotillomania: a case report

Bupropion may be an effective alternative treatment for fluoxetine non-responsive trichotillomania, showing significant improvement in a patient with mesolimbic pathway involvement.

Case Report

2011·

12citations

·R. Bipeta et al.

Systematic review of preclinical, clinical, and post-marketing evidence of bupropion misuse potential

Bupropion shows some potential for misuse, but pharmacological differences from other stimulants limit its reinforcing effects, making it unlikely to require modification of prescribing patterns.

Systematic Review

2019·

8citations

·Andrew C Naglich et al.

Bupropion for overweight women with binge-eating disorder: a randomized, double-blind, placebo-controlled trial.

Bupropion produced modest short-term weight loss in overweight and obese women with binge-eating disorder, but did not improve binge eating, food cravings, or associated eating disorder features or depression.

RCT

2013·

66citations

·M. White et al.

Weight Loss With Naltrexone SR/Bupropion SR Combination Therapy as an Adjunct to Behavior Modification: The COR‐BMOD Trial

Naltrexone SR/Bupropion SR combination therapy effectively aids weight loss and improves cardiometabolic disease risk in obese individuals when combined with intensive behavior modification.

RCTLarge Human TrialVery Rigorous JournalHighly Cited

2011·

470citations

·T. Wadden et al.

Naltrexone/bupropion for obesity: an investigational combination pharmacotherapy for weight loss.

Naltrexone/bupropion combination therapy may effectively reduce obesity by affecting food intake, cravings, and eating behavior through their actions in brain hypothalamic and reward systems.

Highly Cited

2014·

165citations

·S. Billes et al.

Review: Bupropion and SSRI-induced side effects

Bupropion causes less sexual dysfunction than SSRIs and may help reverse SSRI-induced sexual side effects, but its role in weight gain and emotional detachment remains unclear.

Systematic ReviewRigorous JournalHighly Cited

2008·

116citations

·K. Demyttenaere et al.

Naltrexone-Bupropion and Behavior Therapy, Alone and Combined, for Binge-Eating Disorder: Randomized Double-Blind Placebo-Controlled Trial.

Naltrexone-bupropion and behavioral weight loss therapy significantly improve binge-eating disorder, with behavioral weight loss therapy being more effective than no therapy.

RCT

2022·

42citations

·C. Grilo et al.

Bupropion: a systematic review and meta-analysis of effectiveness as an antidepressant

Bupropion is a well-tolerated and effective antidepressant, particularly when combined with other medications, but more research is needed on treatment nave and first presentation depression.

Meta-AnalysisHighly Cited

2016·

139citations

·Krisna Patel et al.

Bupropion for weight reduction

Bupropion shows some efficacy in promoting weight loss in obese patients, but its use is not yet approved by the FDA.

2007·

62citations

·K. Gadde et al.

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