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These studies suggest calcium supplementation, especially when combined with vitamin D, may improve bone mineral density and reduce fracture risk in men, though its effectiveness varies with dosage and population.
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Calcium supplementation is often recommended for various health benefits, including bone health and cardiovascular function. However, the specific effects of calcium supplements on men, particularly in terms of bone mineral density (BMD), cardiovascular health, and overall body composition, have been less extensively studied compared to women. This article synthesizes current research findings on the impact of calcium supplementation in men.
Several studies have investigated the effects of calcium, often in combination with vitamin D, on BMD in men. A systematic review and meta-analysis found that calcium supplementation, with or without vitamin D, significantly improved BMD at various sites, including the total body, total hip, femoral neck, and lumbar spine in healthy males. Another randomized controlled trial (RCT) demonstrated that a daily intake of 1200 mg of calcium increased BMD by 1% to 1.5% more than placebo at all measured sites, whereas a 600 mg dosage was ineffective. These findings suggest that higher doses of calcium, particularly when combined with vitamin D, can be beneficial for bone health in men.
The benefits of calcium and vitamin D supplementation on BMD can be sustained even after discontinuation. An 18-month follow-up study showed that older men who had previously consumed calcium- and vitamin D3-fortified milk maintained the BMD benefits at the femoral neck and ultradistal radius after stopping supplementation. This indicates that the positive effects on bone health can persist beyond the active supplementation period.
The effects of calcium supplementation on cardiovascular health, particularly blood pressure, have been mixed. One study found no significant overall treatment effects on blood pressure in healthy older men over a two-year period. However, a post hoc analysis suggested that men with lower baseline calcium intakes might experience borderline improvements in systolic and diastolic blood pressure with higher calcium supplementation. This implies that calcium supplementation could potentially benefit blood pressure control in men with initially low dietary calcium intake.
While calcium supplements are generally considered safe, there is some evidence suggesting potential cardiovascular risks when calcium is taken without vitamin D. Meta-analytic data have indicated that calcium supplements alone might be associated with an increased risk of cardiovascular events. Therefore, it is recommended to combine calcium with vitamin D to mitigate these risks and enhance overall efficacy.
Research on the impact of calcium supplementation on body composition and weight in men has shown no significant effects. A two-year RCT found no changes in weight, fat mass, or lean mass among men taking calcium supplements compared to those on a placebo. This suggests that calcium supplementation does not influence body composition in healthy men.
Calcium and vitamin D supplements are generally well-tolerated. Studies have shown that these supplements do not significantly affect fasting serum calcium, alkaline phosphatase, creatinine, or parathyroid hormone levels. However, they do increase 24-hour urinary calcium excretion, indicating enhanced calcium absorption. Common side effects such as tooth loss, constipation, and cramps were not significantly different between supplemented and placebo groups.
Calcium supplementation, particularly when combined with vitamin D, can significantly improve BMD in men and may offer sustained benefits even after discontinuation. While the effects on cardiovascular health and body composition are less clear, men with low dietary calcium intake might experience some blood pressure benefits. It is crucial to consider potential cardiovascular risks associated with calcium supplements alone and to ensure adequate vitamin D intake for optimal safety and efficacy.
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