Can albuterol make cough worse

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Can Albuterol Make Cough Worse?

Albuterol and Acute Cough in Non-Asthmatic Children

Research indicates that albuterol does not effectively reduce the frequency or duration of acute cough in non-asthmatic children. In a study involving 59 non-asthmatic children with acute cough, those treated with oral albuterol did not experience a significant reduction in cough compared to those given a placebo. However, the albuterol group did report more side effects such as shaking or trembling 16.

Albuterol and Acute Cough in Adults

Similarly, in adults with acute cough, albuterol has not shown significant benefits. A randomized controlled trial with 104 adults found no difference in cough severity, reduction in sleepless nights, or return to full activity between those treated with albuterol and those given a placebo. The albuterol group did report more side effects, including shakiness and nervousness .

Albuterol and Cough in COPD Patients

In patients with chronic obstructive pulmonary disease (COPD), albuterol has been found to reduce the incidence of wheezing and recurrent cough during the perioperative period. A study involving 120 smoking patients with COPD showed that those treated with albuterol spray had fewer instances of wheezing and recurrent cough compared to those given a placebo .

Albuterol and Cough During Anesthesia Emergence

Albuterol does not appear to affect the frequency or amplitude of cough during emergence from anesthesia. A study involving 68 patients found that the incidence of cough did not differ between those treated with albuterol and those given a placebo. This suggests that albuterol does not prevent cough during the emergence from anesthesia .

Albuterol and Persistent Cough in Asthma

In cases of persistent cough associated with asthma, albuterol may provide some relief, although it is not always effective. For instance, a case study of a 3-year-old female with persistent nonproductive cough showed that albuterol helped somewhat but not consistently . Another study indicated that pretreatment with albuterol could attenuate cough and wheezing caused by beclomethasone aerosol in asthmatic patients .

Conclusion

Overall, while albuterol is effective in reducing wheezing and recurrent cough in COPD patients, it does not significantly reduce acute cough in non-asthmatic children or adults. Additionally, it does not prevent cough during anesthesia emergence. In asthmatic patients, albuterol may help with persistent cough, but its effectiveness can vary. Therefore, while albuterol can be beneficial in specific contexts, it is not universally effective for all types of cough and may sometimes lead to side effects such as shaking and nervousness.

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Most relevant research papers on this topic

Is oral albuterol effective for acute cough in non‐asthmatic children?

Oral albuterol does not reduce the frequency or duration of acute cough in non-asthmatic children with a normal chest examination.

RCT

1999·

17citations

·DW Bernard et al.

The Effect of Albuterol Spray on Hypoxia and Bronchospasm in Patients with Chronic Obstructive Pulmonary Disease (COPD) under General Anesthesia: A bouble-Blind Randomized Clinical Trial

Albuterol spray effectively reduces wheezing and recurrent cough before induction of anesthesia in COPD patients with smoking habits, without significant side effects.

RCT

2023·

1citation

·Seyedmahrokh A. Maddah et al.

Cough During Emergence from Isoflurane Anesthesia

Cough is frequent during emergence from anesthesia, with smoking and albuterol treatment not affecting the occurrence of cough, and patients are unlikely to cough at end-tidal isoflurane concentrations above 0.6%.

RCTHighly Cited

1998·

73citations

·E. S. Kim et al.

A randomized controlled trial of oral albuterol in acute cough.

Oral albuterol is ineffective and may cause increased shakiness and nervousness in unselected patients with acute, nonspecific cough.

RCT

1996·

32citations

·B. Littenberg et al.

Implications of persistent cough in a 3-year-old female.

A 3-year-old female with persistent nonproductive cough was diagnosed with mild persistent asthma and treated with albuterol, beclomethasone, and other medications.

Case Report

2003·

0citations

·A. Khan et al.

Is oral albuterol effective for acute cough in non-asthmatic children?

Oral albuterol is not effective for acute cough in non-asthmatic children, as it does not reduce the frequency or duration of cough.

RCT

2007·

6citations

·DW Bernard et al.

A 57-Year-Old Man With Stridor and Critical Tracheal Narrowing.

A 57-year-old man with polysubstance use and a history of pneumonia had shortness of breath, wheezing, and other symptoms, which worsened over time.

Case Report

2021·

0citations

·B. Alzghoul et al.

Albuterol delivered by metered-dose inhaler to treat acute bronchitis.

Albuterol delivered by metered-dose inhaler reduces the likelihood of patients with acute bronchitis still coughing after 7 days, regardless of cigarette smoking or antibiotic use.

RCT

1994·

65citations

·W. Hueston

ORAL ALBUTEROL INEFFECTIVE FOR ACUTE COUGH.

Oral albuterol is ineffective for acute nonasthmatic cough, as it does not effectively reduce the duration of the cough and does not improve symptoms in patients with bacterial infection.

1996·

0citations

·J. Puffer

Cough and wheezing from beclomethasone aerosol.

Pretreatment with a bronchodilator can effectively reduce cough and wheezing from beclomethasone aerosol therapy, enabling some patients to tolerate it, while others may require oral steroid therapy.

RCT

1987·

57citations

·Chang Shim et al.

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