Can lipitor cause weight loss

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Can Lipitor Cause Weight Loss?

Introduction to Lipitor and Weight Loss

Lipitor, also known as atorvastatin, is a medication primarily used to lower cholesterol levels and reduce the risk of cardiovascular disease. However, there has been some interest in whether Lipitor can also contribute to weight loss. This article synthesizes findings from various studies to explore this potential effect.

Lipitor and Weight Loss: Clinical Evidence

Lipigo® and Weight Reduction

A study investigated the effects of Lipigo®, a product containing a specific β-glucan-chitin-chitosan fraction derived from Saccharomyces cerevisiae, on body weight in overweight and obese individuals. The study was a randomized, double-blind, placebo-controlled clinical trial involving 56 participants. Results showed that while the placebo group experienced an increase in body weight, the group taking Lipigo® saw a slight reduction in body weight, waist circumference, and body fat . This suggests that Lipigo® may aid in weight management for overweight and obese individuals.

Comprehensive Weight Loss Program with Lipigo®

Another study evaluated the impact of Lipigo® on body weight and the rebound effect in obese individuals undergoing a comprehensive weight loss program. This program included a hypocaloric diet, physical activity, and nutritional education. The study found that participants who consumed Lipigo® experienced a significant reduction in body weight and BMI compared to the placebo group. Additionally, the Lipigo® group had a lower rebound effect after 9 months, indicating sustained weight loss benefits .

Mechanism of Action: Lipase Inhibitors

Lipase inhibitors, such as those found in Lipigo®, have been shown to play a role in weight management. These inhibitors prevent the breakdown and absorption of dietary fats, leading to reduced calorie intake and potential weight loss. The review of lipase inhibitors highlights their effectiveness and safety, making them a promising option for obesity treatment .

Conclusion

While Lipitor itself is not directly associated with weight loss, products like Lipigo® that contain specific components derived from Saccharomyces cerevisiae have shown potential in promoting weight reduction and managing obesity. These findings suggest that incorporating such supplements into a comprehensive weight loss program could be beneficial for overweight and obese individuals. However, further research is needed to fully understand the long-term effects and mechanisms involved.

Sources and full results

Most relevant research papers on this topic

Regular Consumption of Lipigo® Promotes the Reduction of Body Weight and Improves the Rebound Effect of Obese People Undergo a Comprehensive Weight Loss Program

Regular consumption of Lipigo® promotes weight reduction and reduces rebound effect in obese individuals undergoing a comprehensive weight loss program after 52 weeks (12 months).

RCTVery Rigorous Journal

2020·

6citations

·M. Valero-Pérez et al.

Lipase Inhibitors for Obesity: A Review.

Pancreatic lipase inhibitors show potential as a safe and effective treatment for obesity due to their structural diversity, low toxicity, and wide range of sources, potentially leading to a new generation of diet pills or healthcare products.

Rigorous JournalHighly Cited

2020·

247citations

·Tian-Tian Liu et al.

Effect of a polysaccharide-rich hydrolysate from Saccharomyces cerevisiae (LipiGo®) in body weight loss: randomised, double-blind, placebo-controlled clinical trial in overweight and obese adults.

Daily supplementation of BGCC from Saccharomyces cerevisiae may improve body weight and waist circumference in overweight and obese individuals without significant adverse effects.

RCTRigorous Journal

2017·

15citations

·J. Santas et al.

Phytochemicals in regulating fatty acid β-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss.

Phytochemicals like citrus flavonoids, green tea epigallocatechin gallate, resveratrol, capsaicin, and curcumin show potential in weight loss by modulating lipid metabolism and increasing BMR and thermogenesis.

Literature ReviewHighly Cited

2016·

144citations

·H. Rupasinghe et al.

Influence of Moringa oleifera flaxseed oil and atorvastatin on hyperlipidemic male albino rats

Moringa oleifera extract can reduce body weight and improve antioxidative enzyme activities in hyperlipidemic male albino rats, while flaxseed oil increases body weight.

RCTAnimal Study

2019·

2citations

·Somia Z Abdelhalim et al.

A Randomized Controlled Trial of Long-Term (R)-α-Lipoic Acid Supplementation Promotes Weight Loss in Overweight or Obese Adults without Altering Baseline Elevated Plasma Triglyceride Concentrations.

Long-term -lipoic acid supplementation promotes weight loss, increased antioxidant enzyme synthesis, and reduced inflammation in overweight adults without altering baseline elevated plasma triglyceride concentrations.

RCTVery Rigorous Journal

2020·

12citations

·G. Bobe et al.

Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis.

Weight reduction through dieting can help normalize blood lipids and lipoproteins in overweight individuals.

Meta-AnalysisHighly Cited

1992·

1083citations

·A M Dattilo et al.

Inhibition of cisplatin-induced lipid catabolism and weight loss by ghrelin in male mice.

Ghrelin prevents cisplatin-induced weight and fat loss by restoring adipose tissue functionality and increasing caloric intake, potentially improving chemotherapy-associated cachexia in cancer patients.

Non-RCTAnimal StudyRigorous JournalHighly Cited

2013·

101citations

·Jose M Garcia et al.

Grape seed and skin extract as an adjunct to xenical therapy reduces obesity, brain lipotoxicity and oxidative stress in high fat diet fed rats.

Combining grape seed and skin extract with Xenical effectively reduces obesity and brain lipotoxicity in high fat diet-fed rats, with GSSE acting partially through its anti-oxidative properties.

RCTAnimal Study

2016·

19citations

·M. Mahmoudi et al.

Effects of alpha-lipoic Acid on body weight in obese subjects.

Alpha-lipoic acid 1800 mg/d led to modest weight loss in obese subjects, suggesting its potential as an adjunctive therapy for obesity.

RCTLarge Human TrialHighly Cited

2011·

150citations

·E. Koh et al.

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