Can lisinopril make you tired

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Can Lisinopril Make You Tired?

Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, is commonly prescribed for the treatment of hypertension and congestive heart failure. While it is generally well-tolerated, some patients may experience side effects, including fatigue.

Fatigue as a Side Effect of Lisinopril

Clinical Observations on Fatigue

Several studies have reported fatigue as a potential side effect of lisinopril. In a large-scale study involving 3,270 patients, fatigue was noted among the most frequent adverse events, although not all instances were directly attributed to lisinopril . Similarly, in a review of international safety data for a combination treatment of lisinopril and hydrochlorothiazide, fatigue was reported in 3.7% of patients . These findings suggest that while fatigue is not the most common side effect, it is a recognized issue for some individuals taking lisinopril.

Comparative Studies with Other Medications

In a comparative study between lisinopril and nifedipine, it was found that tiredness was reported more frequently in the nifedipine-treated group than in the lisinopril-treated group . This indicates that while lisinopril can cause fatigue, it may be less likely to do so compared to some other antihypertensive medications.

Mechanisms and Patient Experiences

Potential Mechanisms

The exact mechanism by which lisinopril may cause fatigue is not fully understood. However, it is known that ACE inhibitors can affect blood pressure regulation and electrolyte balance, which might contribute to feelings of tiredness in some patients 23.

Case Reports and Long-Term Use

In long-term studies, lisinopril has been shown to be well-tolerated, with a side-effect profile similar to other ACE inhibitors . However, individual case reports, such as one involving a patient who developed hepatotoxicity and experienced fatigue, highlight that adverse effects can vary significantly between individuals .

Conclusion

While lisinopril is generally well-tolerated, fatigue is a recognized side effect that affects a minority of patients. Comparative studies suggest that lisinopril may cause less fatigue than some other antihypertensive medications, but individual experiences can vary. Patients experiencing significant fatigue should consult their healthcare provider to discuss potential adjustments to their treatment plan.

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Most relevant research papers on this topic

Lisinopril or nifedipine in essential hypertension? A Norwegian multicenter study on efficacy, tolerability and quality of life in 828 patients.

Lisinopril effectively reduces blood pressure more effectively and is better tolerated than nifedipine in treating mild-to-moderate essential hypertension, with no significant changes in quality of life.

RCTLarge Human Trial

1991·

28citations

·I. Os et al.

Clinical experience with lisinopril. Observations on safety and tolerability.

Lisinopril is well-tolerated for long-term treatment of hypertension and congestive heart failure, with a similar side-effect profile to other ACE inhibitors, but taste disturbance is rarely observed.

Observational Study

1989·

16citations

·H. A. Cameron et al.

Review of international safety data for lisinopril-hydrochlorothiazide combination treatment.

A fixed dose combination of lisinopril-hydrochlorothiazide is a well-tolerated therapeutic option for patients with mild-to-moderate hypertension, with common adverse experiences including dizziness, headache, and fatigue.

Literature Review

1991·

3citations

·Murray Nh

Unique case of presumed lisinopril-induced hepatotoxicity.

Lisinopril-induced hepatotoxicity resolved after discontinuing the drug in a 30-year-old woman with no history of liver-related issues.

Case Report

2010·

7citations

·S. Zalawadiya et al.

Comparative efficacy of lisinopril and nifedipine retard in essential hypertension: a double-blind, placebo-controlled trial.

Lisinopril is better tolerated than nifedipine retard in controlling essential hypertension, but both drugs effectively reduce blood pressure.

RCT

1987·

6citations

·P. Richardson et al.

Lisinopril and nifedipine in essential hypertension: a Norwegian multicenter study on efficacy, tolerability and quality of life in 828 patients.

Lisinopril effectively reduces blood pressure more effectively than nifedipine in patients with mild-to-moderate essential hypertension, and is better tolerated, with fewer withdrawals and lower adverse experiences.

RCTLarge Human Trial

1991·

38citations

·Ingrid Os et al.

[Treatment with lisinopril or nifedipine in essential hypertension. A Norwegian multicenter study of the effect, tolerance and quality of life of 828 patients].

Lisinopril effectively reduces blood pressure and is better tolerated than nifedipine in treating mild to moderate essential hypertension, with fewer adverse experiences and better quality of life.

RCTLarge Human Trial

1992·

1citation

·J. Syvertsen et al.

The Safety and Tolerability of Lisinopril in Clinical Trials

Lisinopril is generally well-tolerated with mild to moderate adverse experiences, rarely requiring discontinuation of therapy.

Observational Study

1987·

62citations

·J. Rush et al.

Short- and long-acting angiotensin-converting enzyme inhibitors: A randomized trial of lisinopril versus captopril in the treatment of congestive heart failure

Lisinopril is superior to captopril in improving exercise duration and quality of life in congestive heart failure patients, particularly in those with renal impairment.

RCTHighly Cited

1989·

118citations

·T. Giles et al.

Short- and long-acting angiotensin-converting enzyme inhibitors: a randomized trial of lisinopril versus captopril in the treatment of congestive heart failure. The Multicenter Lisinopril-Captopril Congestive Heart Failure Study Group.

Lisinopril is superior to captopril in improving exercise duration and quality of life in congestive heart failure patients.

RCT

1989·

8citations

·T. Giles et al.

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