Can losartan cause erectile dysfunction
Pro Research Analysisby 
Searched over 200M research papers
Can Losartan Cause Erectile Dysfunction?
Introduction to Losartan and Erectile Dysfunction
Losartan is an angiotensin II receptor blocker (ARB) commonly used to treat high blood pressure and protect the kidneys from damage due to diabetes. Given its widespread use, understanding its potential side effects, including its impact on erectile function, is crucial.
Losartan and Erectile Function in Diabetic Models
Restoration of Erectile Function in Diabetic Rats
Research indicates that losartan can improve erectile function in diabetic rats. In a study, losartan administration to diabetic rats resulted in the downregulation of the renin-angiotensin system (RAS) components in the corpora cavernosa, leading to a partial restoration of erectile function . This suggests that losartan may counteract the negative effects of diabetes on erectile function by modulating the local RAS.
Suppression of Apoptosis and Oxidative Stress
Further studies have shown that losartan can suppress apoptosis and oxidative stress in the corpus cavernosum, which are significant contributors to erectile dysfunction (ED) in diabetic conditions. This suppression helps in preserving erectile function 39. The combination of losartan with other treatments, such as sildenafil, has been found to be more effective than either treatment alone .
Losartan and Age-Related Erectile Dysfunction
Effects on Aged Rats
In aged rats, losartan has been shown to restore erectile function by reducing oxidative stress and enhancing the expression of endothelial nitric oxide synthase (eNOS) . This indicates that losartan may be beneficial in treating age-related erectile dysfunction (AED) by improving vascular health and reducing oxidative damage.
Clinical Evidence in Humans
Clinical Trials in Diabetic Patients
Clinical trials have demonstrated that losartan can improve erectile function in diabetic patients. In a study involving diabetic patients with ED, losartan significantly improved erectile function scores and the success rates of sexual intercourse . The combination of losartan with tadalafil was found to be more effective than either drug alone, particularly in patients with mild to moderate ED .
Benefits in Hypertensive Patients
Losartan has also been shown to have positive effects on erectile function in hypertensive patients. In a clinical trial, hypertensive men treated with losartan reported significant improvements in erectile function compared to those treated with other antihypertensive drugs . This suggests that losartan may be a preferable option for hypertensive patients concerned about ED.
Mechanisms of Action
Antifibrotic and Antioxidant Properties
Losartan's beneficial effects on erectile function are attributed to its antifibrotic and antioxidant properties. It reduces fibrosis and oxidative stress in the corpus cavernosum, which are critical factors in the development of ED 910. By inhibiting pathways that lead to tissue damage and promoting pathways that support tissue health, losartan helps maintain erectile function.
Modulation of the Renin-Angiotensin System
Losartan's ability to modulate the renin-angiotensin system (RAS) plays a crucial role in its effects on erectile function. By blocking the angiotensin II type 1 receptor, losartan reduces the harmful effects of angiotensin II, such as vasoconstriction and fibrosis, thereby improving blood flow and tissue health in the penis 14.
Conclusion
Contrary to causing erectile dysfunction, losartan appears to have a protective effect on erectile function, particularly in diabetic and hypertensive patients. Its ability to reduce oxidative stress, suppress apoptosis, and modulate the renin-angiotensin system makes it a valuable treatment option for patients at risk of ED. Therefore, losartan not only manages hypertension and diabetic complications but also supports sexual health.
Sources and full results
Most relevant research papers on this topic