Can losartan make you tired
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Can Losartan Make You Tired?
Introduction to Losartan and Its Uses
Losartan is a widely used antihypertensive medication that functions as an angiotensin II receptor blocker (ARB). It is primarily prescribed to manage high blood pressure and to protect the kidneys from damage due to diabetes. However, like many medications, losartan can have side effects, one of which may include fatigue.
Central Fatigue and Neurotransmitter Interaction
Research has shown that losartan can influence central fatigue, which is fatigue originating from the central nervous system. A study involving rats demonstrated that blocking angiotensin II AT1 receptors with losartan led to increased serotonin (5-HT) levels in certain brain areas, such as the preoptic area and hypothalamus, while decreasing serotonin levels in the hippocampus. This imbalance in serotonin levels was associated with increased body heating rates and reduced time to fatigue during exercise, indicating that losartan can indeed induce central fatigue through its effects on brain serotonin and dopamine content.
Clinical Observations in Older Adults
In a pilot study involving prefrail older adults, losartan was observed to cause fatigue among other side effects such as hyperkalemia and hypotension. Despite its benefits in reducing frailty and improving physical function, the occurrence of fatigue was notable among the participants receiving losartan treatment. This suggests that while losartan can have positive effects on physical health, it may also contribute to feelings of tiredness in some individuals.
Tumor-Induced Fatigue and Muscle Wasting
Another study focused on cancer patients revealed that losartan could mitigate tumor-induced myocardial dysfunction and muscle wasting, which are common causes of fatigue in this population. By preventing the loss of muscle mass and improving myocardial function, losartan helped reduce the overall fatigue experienced by cancer patients. However, the study also highlighted that fatigue is a complex symptom influenced by multiple factors, including inflammation and muscle degradation.
Conclusion
In summary, losartan can indeed make you tired, primarily through its effects on central fatigue mechanisms and neurotransmitter interactions. While it has beneficial effects in managing hypertension and improving physical function in certain populations, the side effect of fatigue should be considered, especially in older adults and those with cancer. If you are experiencing significant tiredness while taking losartan, it is advisable to consult with your healthcare provider to discuss potential adjustments to your treatment plan.
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