Can prednisolone cause yeast infection

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Prednisolone and Yeast Infections: Analyzing the Risks

Prednisolone and Increased Susceptibility to Infections

Prednisolone, a corticosteroid commonly used to treat various inflammatory and autoimmune conditions, has been shown to increase susceptibility to infections. This is particularly evident in patients with severe alcoholic hepatitis (SAH), where prednisolone treatment has been associated with a higher incidence of serious infections. A study involving 1092 patients revealed that those treated with prednisolone had a significantly higher risk of developing serious infections compared to those who did not receive the drug . This increased risk of infection can lead to higher mortality rates, emphasizing the need for careful monitoring and management of patients on prednisolone therapy.

Prednisolone and Yeast Infections in Specific Conditions

Experimental Candida Infections in Dairy Cattle

In an experimental study on dairy cattle, the growth of Candida krusei in mammary glands treated with a combination of penicillin, dihydrostreptomycin, and prednisolone was compared to untreated glands. The results indicated that while the number of leukocytes increased during treatment, the number of yeast organisms isolated remained the same or decreased, suggesting that prednisolone did not significantly promote yeast growth in this context .

Immunosuppressive Therapy and Yeast Contamination

Patients with kidney diseases receiving immunosuppressive therapy, including prednisolone, showed increased contamination with yeast-like fungi and a higher incidence of candidiasis. This was more pronounced when prednisolone was combined with azathioprine, compared to cyclophosphamide. The study highlighted the need for antifungal prophylaxis and careful monitoring of yeast infections in patients undergoing such treatments .

Case of Fulminant Candidemia

A case report described a 77-year-old man treated with prednisolone for pemphigus who developed severe sepsis and candidemia. Despite prompt antifungal treatment, the patient did not recover, and autopsy revealed widespread yeast infection. This case underscores the potential severity of yeast infections in patients on prednisolone, particularly when combined with other immunosuppressive agents .

Combined Treatments and Yeast Infections

Corticosteroids and Antifungal Therapy

In a study on experimental Candida albicans keratitis in rabbits, the combination of fluconazole and prednisolone was evaluated. The results suggested that delayed administration of high-dose prednisolone after initial antifungal treatment did not significantly increase the recultivation rate of C. albicans, indicating that corticosteroids might be safely used in conjunction with antifungal therapy if timed appropriately .

Conclusion

Prednisolone can indeed increase the risk of yeast infections, particularly in patients with compromised immune systems or those receiving combined immunosuppressive therapies. While some studies suggest that prednisolone does not significantly promote yeast growth in certain experimental conditions, clinical evidence points to a heightened risk of serious infections, including candidiasis, in patients treated with this corticosteroid. Careful monitoring and appropriate antifungal prophylaxis are essential to mitigate these risks.

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Most relevant research papers on this topic

In Patients With Severe Alcoholic Hepatitis, Prednisolone Increases Susceptibility to Infection and Infection-Related Mortality, and Is Associated With High Circulating Levels of Bacterial DNA

Prednisolone treatment in severe alcoholic hepatitis patients increases susceptibility to infection and infection-related mortality, and is associated with high circulating bacterial DNA levels.

RCTLarge Human TrialHighly Cited

2017·

159citations

·N. Vergis et al.

The effect of penicillin, dihydrostreptomycin and prednisolone treatment of experimental Candida krusei infections of the mammary glands of dairy cattle.

Penicillin, dihydrostreptomycin, and prednisolone effectively treat experimental Candida krusei infections in dairy cattle without causing clinical mastitis.

1975·

9citations

·R. Farnsworth et al.

[Drug sensitivity of Candida in patients with kidney diseases receiving immunosuppressive therapy].

Immunodepressants and antifungal drugs can enhance the antifungal activity of Candida in kidney disease patients, with prednisolone and its combination with azathioprine being particularly harmful.

In Vitro Study

1989·

3citations

·V. M. Kudriavskaia et al.

Fulminant candidemia diagnosed by prompt detection of pseudohyphae in a peripheral blood smear.

Prompt detection of yeast pseudohyphae in a peripheral blood smear can accurately diagnose fulminant candidemia, potentially saving lives.

Case Report

2012·

2citations

·S. Ikegaya et al.

Reply to “Not Over Yet: Fungal Infections following Methyl Prednisolone Injections Smoulder On”

Fungal infections following methyl prednisolone injections in the United States continue to erupt, with meningitis being the most frequent consequence and other infections including arachnoiditis, spinal infection, and peripheral joint infection.

Rigorous Journal

2014·

1citation

·Yanan Zhao et al.

Combined topical fluconazole and corticosteroid treatment for experimental Candida albicans keratomycosis.

Fluconazole plus high-dose prednisolone treatment is most effective when administered 9 days after infection, with delayed application not contraindicated and potentially beneficial in patients.

RCTAnimal StudyHighly Cited

2003·

85citations

·W. Schreiber et al.

Probiotic yeasts: anti-inflammatory potential of various non-pathogenic strains in experimental colitis in mice.

A careful selection of yeast strains is needed for specific clinical studies, as some show significant anti-inflammatory activities in a mouse model of TNBS-induced colitis, while others show weaker or no preventive effect.

In Vitro StudyHighly Cited

2010·

76citations

·B. Foligné et al.

The Effect of Prednisolone on Canine Neutrophil Function: In Vivo and in Vitro Studies

Prednisolone reduces canine neutrophil adherence and increases their functional capacity, potentially contributing to their antiinflammatory effect.

In Vitro Study

1998·

16citations

·G. Trowald-Wigh et al.

Prednisolone

Prednisolone therapy may contribute to the development of Legionella longbeachae infection, and reducing prednisolone dose can improve patient's condition.

Case Report

2020·

0citations

Systemic candidiasis in mice treated with prednisolone and amphotericin B. 1. Morbidity, mortality and inflammatory reaction

Prednisolone can exacerbate candidiasis in mice, but amphotericin B can prevent death or reduce severity when used together.

Non-RCTAnimal Study

1978·

2citations

·W. Blyth et al.

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