Can prednisone cause yeast infection
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Prednisone and Its Association with Yeast Infections
Prednisone and Increased Susceptibility to Infections
Prednisone, a commonly used glucocorticoid, is known for its potent anti-inflammatory and immunosuppressive properties. However, its use has been linked to an increased risk of infections, including fungal infections. Studies have shown that patients treated with prednisone are more susceptible to developing serious infections due to its immunosuppressive effects . This increased susceptibility is particularly concerning in patients with compromised immune systems, such as those with severe alcoholic hepatitis (SAH), where prednisolone (a form of prednisone) treatment has been associated with a higher incidence of serious infections and infection-related mortality .
Fungal Infections in Animals Treated with Prednisone
Research has also documented cases of fungal infections in animals treated with prednisone. For instance, a case study reported a bone marrow infection caused by Phialosimplex caninus in a dog receiving prednisone for autoimmune hemolytic anemia. The infection was characterized by the presence of yeast-like cells and hyphae in the bone marrow . Similarly, a case of systemic Cryptococcus albidus infection was reported in a cat treated with prednisone, highlighting the potential for prednisone to predispose animals to severe fungal infections .
Dysbiosis of Gut Mycobiome Due to Long-term Prednisone Use
Long-term use of prednisone has been shown to cause dysbiosis of the gut mycobiome, altering the ecological interactions between gut fungi and bacteria. In a study involving rats, prolonged prednisone treatment led to significant changes in the diversity and composition of gut fungi, including an increase in the relative abundance of certain fungal species such as Aspergillus glabripes . This dysbiosis can disrupt the balance of the gut microbiome, potentially leading to overgrowth of pathogenic fungi and subsequent infections.
Prednisone and Oropharyngeal Candidiasis
Oropharyngeal candidiasis, a common yeast infection, has been observed in patients treated with inhaled corticosteroids like beclomethasone, especially when used without a spacer device. A study comparing the incidence of Candida infection in patients using beclomethasone with and without an Aerochamber found that those using the Aerochamber had a significantly lower incidence of Candida infection and colonization. Additionally, these patients were more likely to reduce their dependency on oral prednisone . This suggests that the method of corticosteroid delivery can influence the risk of developing yeast infections.
Conclusion
In summary, prednisone can indeed increase the risk of yeast infections due to its immunosuppressive effects. This risk is evident in both human and animal studies, with documented cases of serious fungal infections and gut mycobiome dysbiosis. The method of corticosteroid delivery also plays a role in the incidence of infections, as seen in the reduced rates of oropharyngeal candidiasis with the use of an Aerochamber. Therefore, while prednisone is effective for its intended therapeutic uses, its potential to cause yeast infections should be carefully considered and monitored.
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