Can probiotics cause nausea

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Can Probiotics Cause Nausea?

Introduction to Probiotics and Their Uses

Probiotics are live microorganisms that, when administered in adequate amounts, confer health benefits to the host. They are widely used to improve gut health and treat various gastrointestinal disorders. However, like any supplement, probiotics can have side effects, including gastrointestinal issues such as nausea.

Probiotics and Gastrointestinal Side Effects

Nausea and Chemotherapy Patients

Several studies have investigated the effects of probiotics on chemotherapy-induced gastrointestinal side effects, including nausea. A systematic review of multiple studies found that probiotics could significantly reduce the severity of chemotherapy-related side effects, including nausea, in some cases 123. However, the heterogeneity of the data makes it difficult to draw firm conclusions about their overall effectiveness.

General Safety and Side Effects

Probiotics are generally considered safe, but they can cause gastrointestinal side effects such as nausea, diarrhea, flatulence, and abdominal pain . These side effects are usually mild and temporary, but they can be more severe in certain populations, such as those with compromised immune systems.

Specific Studies on Nausea

A study on the administration of probiotics to colorectal cancer patients undergoing chemotherapy found that probiotics could effectively reduce gastrointestinal complications, including nausea . Another study focusing on children with acute lymphoblastic leukemia receiving chemotherapy also noted a reduction in nausea with the use of synbiotics, which are supplements containing both probiotics and prebiotics .

Conclusion

While probiotics are generally safe and can be beneficial in reducing certain gastrointestinal side effects, including nausea, they can also cause nausea in some individuals. The severity and occurrence of this side effect can vary depending on the individual's health condition and the specific strains of probiotics used. Therefore, it is essential to consult healthcare providers before starting any probiotic regimen, especially for individuals undergoing treatments like chemotherapy.

Sources and full results

Most relevant research papers on this topic

Influence of Probiotics in Prevention and Treatment of Patients Who Undergo Chemotherapy or/and Radiotherapy and Suffer from Mucositis, Diarrhoea, Constipation, Nausea and Vomiting

Probiotics may have a significant impact on reducing the severity of gastrointestinal side effects in patients undergoing chemotherapy and radiotherapy, but more research is needed for a firm conclusion.

Systematic ReviewRigorous Journal

2022·

13citations

·Aleksandra Garczyk et al.

The effects of LactoCare synbiotic administration on chemotherapy‐induced nausea, vomiting, diarrhea, and constipation in children with ALL: A double‐blind randomized clinical trial

LactoCare synbiotic administration may reduce chemotherapy-induced nausea, vomiting, diarrhea, and constipation in children with acute lymphoblastic leukemia receiving maintenance chemotherapy.

RCT

2023·

11citations

·A. Eghbali et al.

The effect of probiotic and synbiotic consumption on the most prevalent chemotherapy-related complications: A systematic review of current literature.

Probiotics may be more effective in treating mucositis compared to other chemotherapy-related side effects, but further high-quality randomized controlled trials are needed to confirm their effectiveness.

Systematic Review

2022·

6citations

·Arman Arab et al.

Study protocol of a double-blind randomised placebo-controlled trial on the effect of a multispecies probiotic on the incidence of antibiotic-associated diarrhoea in persons with spinal cord injury

A multispecies probiotic may prevent antibiotic-associated diarrhoea in people with spinal cord injury, improving bowel management, nausea, and quality of life.

RCT

2019·

8citations

·W. Faber et al.

Postoperative Probiotics Administration Attenuates Gastrointestinal Complications and Gut Microbiota Dysbiosis Caused by Chemotherapy in Colorectal Cancer Patients

Probiotics effectively reduce chemotherapy-induced gastrointestinal complications and improve gut microbiota diversity in colorectal cancer patients.

RCT

2023·

60citations

·Feng Huang et al.

Safety of Probiotics

Probiotics are generally considered safe, but common use may increase the risk of side effects, including gastrointestinal disorders, respiratory infections, and allergic reactions.

2018·

1citation

·D. Zielińska et al.

Meta-analysis of the efficacy of probiotics in Helicobacter pylori eradication therapy.

Probiotics during standard triple H. pylori therapy may improve eradication rates and reduce the incidence of total adverse effects.

Meta-AnalysisRigorous JournalHighly Cited

2014·

90citations

·Rong-Ying Zhu et al.

Probiotics supplementation for athletes – Clinical and physiological effects

Probiotic supplementation in athletes may reduce the frequency and severity of respiratory and gastrointestinal illnesses.

Highly Cited

2015·

117citations

·D. Pyne et al.

Hypocholesterolaemic effect and anti-hypertensive properties of probiotics and prebiotics: A review

Hypercholesterolaemia (HCE) and hypertension (HT) are two major contributing factors in development of cardiovascular disease (CVD). As synthetic medications used to treat HCE and HT can cause several side effects such as nausea, vomiting and abdominal pain, various dietary approaches have been proposed to improve the HCE and HT at the population level. Most popular dietary intervention includes the use of probiotics and prebiotics in the development of functional foods. This review covers (1) the hypocholesterolaemic effects and anti-hypertensive properties of probiotics and prebiotics via several mechanisms, (2) the evidence generated from both in vitro experiments and in vivo trials and some controversial findings that are raised, (3) the effective dosage of prebiotics and probiotics, and (4) safety issues regarding the use of probiotics and prebiotics in human diet.

Literature Review

2016·

47citations

·Fatemeh Miremadi et al.

Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy

Probiotic supplementation significantly reduces nausea, vomiting, and constipation during early pregnancy, improving life quality and potentially facilitating intestinal mobility and metabolism.

Very Rigorous Journal

2021·

16citations

·A. T. Liu et al.

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