Can you take losartan and amlodipine together

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Co-Administration of Losartan and Amlodipine: Efficacy and Safety

Introduction to Losartan and Amlodipine Combination Therapy

Losartan, an angiotensin receptor blocker (ARB), and amlodipine, a calcium channel blocker (CCB), are commonly prescribed medications for managing hypertension. Combining these two drugs can potentially enhance blood pressure control through complementary mechanisms of action. This article explores the pharmacokinetics, efficacy, and safety of co-administering losartan and amlodipine based on recent research findings.

Pharmacokinetics of Losartan and Amlodipine Combination

Studies have shown that the pharmacokinetic profiles of losartan and amlodipine are not significantly altered when administered together. A fixed-dose combination (FDC) of losartan and amlodipine has been found to be bioequivalent to the separate administration of the two drugs, indicating that their absorption and metabolism remain consistent whether taken together or separately 125. Specifically, the geometric mean ratios for the area under the concentration-time curve (AUC) and maximum plasma concentration (Cmax) for both drugs fall within the acceptable range for bioequivalence 15.

Efficacy of Combined Losartan and Amlodipine Therapy

The combination of losartan and amlodipine has demonstrated superior efficacy in reducing blood pressure compared to monotherapy with either drug alone. In a study involving patients with inadequately controlled hypertension, the single-pill combination of amlodipine and losartan significantly reduced both systolic and diastolic blood pressure compared to losartan monotherapy . Another study confirmed that the combination therapy resulted in greater reductions in 24-hour brachial and central blood pressure, particularly in patients with advanced arterial stiffness .

Safety and Tolerability

The co-administration of losartan and amlodipine is generally well-tolerated. Research indicates that the incidence of adverse events is not significantly different between the combination therapy and monotherapy, and both treatments are considered safe 2510. However, some studies have noted specific side effects associated with each drug. For instance, amlodipine is more likely to cause peripheral edema, while losartan may lead to dizziness upon standing . Despite these side effects, the overall safety profile of the combination therapy remains favorable.

Conclusion

Combining losartan and amlodipine offers a potent and safe option for managing hypertension, particularly in patients who do not achieve adequate blood pressure control with monotherapy. The pharmacokinetic compatibility and enhanced efficacy of the combination therapy make it a valuable strategy in hypertension management. As always, patients should consult their healthcare providers to determine the most appropriate treatment plan for their individual needs.

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Most relevant research papers on this topic

Comparison of Pharmacokinetics of a Fixed-Dose Combination of Amlodipine/Losartan/Rosuvastatin with Concomitant Administration of Amlodipine/Losartan and Rosuvastatin in Healthy Volunteers

The fixed-dose combination of amlodipine/losartan/rosuvastatin 5/100/20 mg is a pharmacokinetically equivalent replacement for concomitant administration, potentially improving medication compliance in patients with hypertension and dyslipidemia.

RCTRigorous Journal

2020·

2citations

·D. Y. Yoon et al.

Comparisons of the pharmacokinetics and tolerability of fixed-dose combinations of amlodipine besylate/losartan and amlodipine camsylate/losartan in healthy subjects: a randomized, open-label, single-dose, two-period, two-sequence crossover study

An FDC of 6.94 mg amlodipine besylate/5 mg losartan potassium is similar to an FDC of 5 mg amlodipine camsylate/5 mg losartan potassium in pharmacokinetics and tolerability in healthy male subjects.

RCTRigorous Journal

2016·

11citations

·Yoonjung Choi et al.

Add-on effect of hydrochlorothiazide 12.5 mg in Japanese subjects with essential hypertension uncontrolled with losartan 50 mg and amlodipine 5 mg

L50/H12.5/A5 showed a nominally significant difference in systolic blood pressure reduction compared to L50+A5 in Japanese subjects with uncontrolled essential hypertension, but was well-tolerated.

RCTLarge Human Trial

2015·

12citations

·H. Rakugi et al.

[PP.12.23] A RANDOMIZED, MULTICENTER, DOUBLE-BLIND, PHASE III STUDY TO EVALUATE THE EFFICACY AND SAFETY OF THE TRIPLE COMBINATION OF AMLODIPINE/LOSARTAN/ROSUVASTATIN IN PATIENTS WITH ESSENTIAL HYPERTENSION

The triple combination of amlodipine/losartan/rosuvastatin effectively reduces LDL-cholesterol levels and lowers blood pressure in patients with essential hypertension, without significantly differing in adverse events.

RCTVery Rigorous Journal

2017·

0citations

·H. Lee et al.

Bioequivalence of losartan/amlodipine fixed dose combination tablets (losanet AM) compared with concomitant administration of Single components of losartan and amlodipine tablets in healthy human volunteers

Losartan and amlodipine are bioequivalent and well-tolerated when administered as a fixed dose combination or individual tablets in healthy human volunteers.

RCT

2015·

6citations

·R. Bustami et al.

Main results of the losartan versus amlodipine (LOA) study on drug tolerability and psychological general well‐being

Losartan and amlodipine effectively lower blood pressure, but amlodipine has higher drug-related adverse effects and withdrawal rates.

RCTLarge Human Trial

1997·

57citations

·B. Dahlöf et al.

Comment on ‘Comparison of losartan and amlodipine effects on the outcomes of patient with COVID‐19 and primary hypertension: A randomised clinical trial’

Losartan may have a faster steady-state effect than amlodipine in COVID-19 patients with primary hypertension, potentially favoring its use.

RCTLarge Human TrialRigorous Journal

2021·

1citation

·G. Loas et al.

Pharmacokinetic and haemodynamic interactions between amlodipine and losartan in human beings

Co-administration of amlodipine and losartan is tolerable and does not cause substantial pharmacokinetic interaction, but combination use causes additive haemodynamic changes compared to either drug alone.

2019·

10citations

·Jin-Woo Park et al.

LOSARTAN/AMLODIPINE IN ARTERIAL STIFFNESS SHOWS DOMINANT EFFICACY IN REDUCING 24 HOURS BRACHIAL AND CENTRAL BP COMPARED WITH LOSARTAN/HYDROCHLOROTHIAZID OR IN NORMAL ARTERY

Losartan/amlodipine combination therapy is more effective in reducing 24 hours brachial and central blood pressure in patients with advanced arterial stiffness compared to losartan/hydrochlorothiazide or normal arterial patients.

RCT

2023·

0citations

·E. Cho et al.

Efficacy and safety of single-pill amlodipine/losartan versus losartan in patients with inadequately controlled hypertension after losartan treatment: a multicenter, double-blind, randomized phase III clinical trial

Single-pill amlodipine/losartan is superior to losartan monotherapy for controlling blood pressure and is safe and well-tolerated in Chinese patients with inadequately controlled hypertension after losartan treatment.

RCTLarge Human Trial

2023·

0citations

·Shu-you Zhang et al.

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