Can you take zinc and vitamin d together

Pro Research Analysisby

Searched over 200M research papers

Analyzed relevant papers

Can You Take Zinc and Vitamin D Together?

Introduction to Zinc and Vitamin D Co-Supplementation

Zinc and vitamin D are essential nutrients that play crucial roles in various bodily functions, including immune modulation, bone health, and mental well-being. Recent studies have explored the potential benefits and interactions of taking these supplements together.

Effects on Mental Health and Depression

Research has shown that co-supplementation of zinc and vitamin D can have significant positive effects on mental health, particularly in individuals with obesity and depressive symptoms. A study involving obese/overweight patients with depressive symptoms found that supplementation with zinc, vitamin D, or a combination of both significantly decreased depression scores compared to a placebo group . This suggests that taking these supplements together can be beneficial for mental health.

Impact on Inflammation and Oxidative Stress

Co-supplementation of zinc and vitamin D, along with other nutrients like magnesium and calcium, has been shown to reduce biomarkers of inflammation and oxidative stress. For instance, in women with gestational diabetes, a combination of magnesium, zinc, calcium, and vitamin D significantly reduced serum high-sensitivity C-reactive protein and plasma malondialdehyde concentrations, while increasing total antioxidant capacity . Similar benefits were observed in women with polycystic ovary syndrome (PCOS) .

Immune System and Infection Resistance

Zinc and vitamin D are known for their roles in immune modulation. Studies have indicated that these nutrients can enhance the body's resistance to infections, including viral infections like COVID-19. A systematic review highlighted that low levels of zinc and vitamin D were associated with increased severity of COVID-19, suggesting that adequate levels of these nutrients could improve outcomes . Another study on schoolchildren found that vitamin D and zinc supplementation improved vitamin D status but did not significantly affect infection rates compared to a placebo .

Nutrient Interactions and Absorption

The interaction between zinc and vitamin D has been studied in various contexts. For example, in animal studies, vitamin D was found to influence zinc absorption and metabolism. Increased dietary calcium and vitamin D led to higher excretion of zinc in feces, indicating that vitamin D affects zinc absorption at the site of the intestine . However, other studies have shown that co-supplementation does not necessarily lead to increased zinc loss, suggesting that the interaction may depend on specific conditions and dosages .

Conclusion

Taking zinc and vitamin D together can offer several health benefits, including improved mental health, reduced inflammation, and enhanced immune function. While there are some interactions between these nutrients that may affect absorption and metabolism, the overall evidence supports the safety and efficacy of their co-supplementation. Therefore, individuals considering these supplements can take them together, but it is always advisable to consult with a healthcare provider to tailor the supplementation to individual health needs and conditions.

Sources and full results

Most relevant research papers on this topic

Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial.

Zinc and vitamin D supplements, or their combination, significantly reduced depressive symptoms in obese or overweight patients with BDI-II 10.

RCT

2019·

27citations

·Somaye Yosaee et al.

The effects of magnesium-zinc-calcium-vitamin D co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes

Magnesium-zinc-calcium-vitamin D co-supplementation for 6 weeks may reduce inflammation and oxidative stress in women with gestational diabetes, potentially improving pregnancy outcomes.

RCTRigorous JournalHighly Cited

2019·

104citations

·M. Jamilian et al.

Interactions of dietary zinc and vitamin D in laying hens.

Dietary zinc and vitamin D interact to increase bone radiozinc in laying hens, with the effect being at the site of absorption.

1967·

3citations

·D. K. Schisler et al.

Zinc, ω-3 polyunsaturated fatty acids and vitamin D: An essential combination for prevention and treatment of cancers.

Zinc, -3 PUFAs, and vitamin D have similar anti-cancer properties and can be combined for beneficial treatment or supplementation, potentially requiring sufficient sufficiency during chemotherapy.

Literature Review

2020·

10citations

·M. J. Story

The relationship between COVID-19, Zinc and Vitamin D: A Systematic Review

Low zinc levels and COVID-19 are associated with increased hospitalization risk, and vitamin D deficiency may contribute to severe COVID-19 in adults.

Systematic Review

2022·

0citations

·Najlaa Mohammad Alsudairy et al.

Vitamin D and Zinc are Interlinked but Affected by Different Growth Factors in Iranian Children and Adolescents: Vitamin D and Zinc in Iranian Children and Adolescents

Low vitamin D levels in Iranian children are linked to zinc deficiency, with vitamin D insufficiency being more prevalent in overweight and obese children, and both factors affecting BMI and height z-scores.

2022·

2citations

·Ashkan Habib et al.

Magnesium-Zinc-Calcium-Vitamin D Co-supplementation Improves Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial

Magnesium-zinc-calcium-vitamin D co-supplementation for 12 weeks improves hormonal profiles, biomarkers of inflammation, and oxidative stress in women with polycystic ovary syndrome.

RCT

2017·

48citations

·Maryam Maktabi et al.

Effect of Calcium and Vitamin D on Zinc Balance in Rats

Vitamin D fortification in a diet low in calcium leads to increased urinary loss of zinc and calcium, contradicting previous data on zinc deficiency risk when enriched with calcium.

Very Rigorous Journal

2022·

1citation

·A. Korolev et al.

Occurrence of infections in schoolchildren subsequent to supplementation with vitamin D-calcium or zinc: a randomized, double-blind, placebo-controlled trial

Vitamin D-calcium supplementation improves vitamin D status but does not significantly affect the occurrence of infections in rural Indian schoolchildren.

RCTLarge Human TrialVery Rigorous Journal

2019·

15citations

·R. Mandlik et al.

Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19

Early micronutrient interventions with zinc, selenium, and vitamin D may help reduce inflammation and protect against COVID-19 progression.

Systematic ReviewVery Rigorous JournalHighly Cited

2020·

194citations

·J. Alexander et al.

Try another search

mental disorder terms

can a traumatic event cause depression

facts obsessive compulsive disorder

viral pneumonia rash

season influenza

symptoms of depression in teenagers

Can you take zinc and vitamin d together

Pro Research Analysisby

Can You Take Zinc and Vitamin D Together?

Introduction to Zinc and Vitamin D Co-Supplementation

Effects on Mental Health and Depression

Impact on Inflammation and Oxidative Stress

Immune System and Infection Resistance

Nutrient Interactions and Absorption

Conclusion

Sources and full results

Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial.

Zinc and vitamin D supplements, or their combination, significantly reduced depressive symptoms in obese or overweight patients with BDI-II 10.

The effects of magnesium-zinc-calcium-vitamin D co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes

Magnesium-zinc-calcium-vitamin D co-supplementation for 6 weeks may reduce inflammation and oxidative stress in women with gestational diabetes, potentially improving pregnancy outcomes.

Interactions of dietary zinc and vitamin D in laying hens.

Dietary zinc and vitamin D interact to increase bone radiozinc in laying hens, with the effect being at the site of absorption.

Zinc, ω-3 polyunsaturated fatty acids and vitamin D: An essential combination for prevention and treatment of cancers.

Zinc, -3 PUFAs, and vitamin D have similar anti-cancer properties and can be combined for beneficial treatment or supplementation, potentially requiring sufficient sufficiency during chemotherapy.

The relationship between COVID-19, Zinc and Vitamin D: A Systematic Review

Low zinc levels and COVID-19 are associated with increased hospitalization risk, and vitamin D deficiency may contribute to severe COVID-19 in adults.

Vitamin D and Zinc are Interlinked but Affected by Different Growth Factors in Iranian Children and Adolescents: Vitamin D and Zinc in Iranian Children and Adolescents

Low vitamin D levels in Iranian children are linked to zinc deficiency, with vitamin D insufficiency being more prevalent in overweight and obese children, and both factors affecting BMI and height z-scores.

Magnesium-Zinc-Calcium-Vitamin D Co-supplementation Improves Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial

Magnesium-zinc-calcium-vitamin D co-supplementation for 12 weeks improves hormonal profiles, biomarkers of inflammation, and oxidative stress in women with polycystic ovary syndrome.

Effect of Calcium and Vitamin D on Zinc Balance in Rats

Vitamin D fortification in a diet low in calcium leads to increased urinary loss of zinc and calcium, contradicting previous data on zinc deficiency risk when enriched with calcium.

Occurrence of infections in schoolchildren subsequent to supplementation with vitamin D-calcium or zinc: a randomized, double-blind, placebo-controlled trial

Vitamin D-calcium supplementation improves vitamin D status but does not significantly affect the occurrence of infections in rural Indian schoolchildren.

Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19

Early micronutrient interventions with zinc, selenium, and vitamin D may help reduce inflammation and protect against COVID-19 progression.

Try another search

Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial.