Cancer in remission
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Summary
10 papers analyzed
These studies suggest that cancer remission can be influenced by various factors including treatment type, patient demographics, and disease characteristics, with some treatments showing promise in achieving remission in specific cancers.
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Understanding Cancer Remission: Insights from Recent Research
Concept of Cancer Remission in Survivorship
Keywords: cancer remission, survivorship, psychological impact
Cancer remission is a critical milestone in the journey of cancer survivorship, often defined as the period during which a patient shows no measurable or symptomatic evidence of disease. However, the term "remission" encompasses a range of physical and psychological experiences. Research highlights that while patients in remission are generally free from active disease, they often face anxiety, fear of recurrence, and a loss of social support. Positive outcomes such as acceptance of the treatment journey, appreciation for life, and hope are also common, but these are frequently accompanied by persistent anxiety and triggered memories. Effective communication between healthcare providers and survivors is essential to address these complex experiences and improve patient-centered care.
Clinical Features and Treatment Modalities for Complete Remission in Advanced Lung Cancer
Keywords: non-small cell lung cancer, complete remission, treatment modalities
Achieving complete remission (CR) in advanced non-small cell lung cancer (NSCLC) remains rare, but certain clinical features and treatment strategies have been identified as key factors. Long-term survivors of stage III and IV NSCLC who achieved CR often had smaller primary tumors and fewer metastases. Treatment typically involved multiple lines of chemotherapy, with primary and oligometastatic controls managed through surgery and/or radiation. Notably, a strong immune response characterized by the presence of inflammatory cells around resected tumors was observed in CR patients, suggesting that robust immune activity may play a role in achieving remission.
Spontaneous Remission in Cancer: Rare but Possible
Keywords: spontaneous remission, lung cancer, immune response
Spontaneous remission (SR) in cancer, defined as the unexpected regression of a malignant disease without adequate medical treatment, is an extremely rare phenomenon. Documented cases, such as a patient with metastatic non-small cell lung cancer who experienced complete SR of abdominal wall metastases and subsequent disappearance of liver and lung metastases, highlight the potential for the body's immune system to combat cancer. Another case reported SR in a lung carcinoma patient following adjuvant immunotherapy, where a strong immune response involving CD8+ T cells and other immune cells was observed. These cases underscore the complexity and potential of the immune system in achieving cancer remission.
Impact of the COVID-19 Pandemic on Remission Rates in Ovarian Cancer
Keywords: ovarian cancer, COVID-19 pandemic, remission outcomes
The COVID-19 pandemic posed significant challenges for cancer treatment, yet studies indicate that remission rates for ovarian cancer patients remained relatively stable. A comparison of remission outcomes before and during the pandemic showed no significant differences in complete or clinical remission rates. However, racial disparities were noted, with Black patients experiencing lower complete remission rates during the pandemic compared to pre-pandemic periods, highlighting the need for further investigation into the impact of healthcare disruptions on different demographic groups.
Long-Term Remission in Metastatic Breast Cancer
Keywords: metastatic breast cancer, long-term remission, combination chemotherapy
Long-term remission in metastatic breast cancer (MBC) is achievable, though rare. Patients who achieved complete remission with combination chemotherapy often had lower tumor burdens and better performance statuses. The median duration of complete remission was 17 months, with some patients remaining in remission for over five years . These findings suggest that while most MBC patients experience temporary responses, a subset can achieve prolonged remission, emphasizing the need for consolidation treatments to extend these outcomes.
Remission and Survival in Leukemia
Keywords: leukemia, remission, survival rates
In leukemia, achieving remission is crucial for long-term survival. Studies show that initial central nervous system (CNS) relapse can lead to poorer hematological remission and survival outcomes. Innovative treatments, such as CD19-targeted T cells, have shown promise in inducing rapid molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia (ALL), providing a potential bridge to curative therapies like hematopoietic stem cell transplantation.
Conclusion
Cancer remission, whether achieved through conventional treatments, spontaneous regression, or advanced immunotherapies, represents a complex and multifaceted outcome. Understanding the clinical features, treatment modalities, and psychological impacts associated with remission can help improve patient care and long-term survivorship. Continued research and tailored treatment strategies are essential to enhance remission rates and quality of life for cancer patients.
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