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These studies suggest that cardiovascular disease prevalence and mortality are influenced by health inequalities, social determinants, and resource disparities between high-income and middle-income countries, with significant impacts on global health.
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Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality worldwide. The prevalence and impact of CVD vary significantly across different regions and income levels. In the European Society of Cardiology (ESC) member countries, the burden of CVD is notably higher in middle-income countries compared to high-income countries. Middle-income countries experience approximately 30% higher incidence rates of CVD, and the disability-adjusted life years (DALYs) due to CVD are nearly four times higher than in high-income countries .
Life expectancy in ESC member countries shows a stark contrast between high-income and middle-income nations. Females born in high-income countries are expected to live 81.6 years, while those in middle-income countries have a life expectancy of 74.2 years. Similarly, healthcare expenditure in high-income countries is, on average, four times higher than in middle-income countries.
Environmental factors such as air quality also play a significant role in cardiovascular health. Median PM2.5 concentrations in middle-income ESC member countries are over twice as high as in high-income countries, often exceeding EU air quality standards. Additionally, the prevalence of obesity has more than doubled over the past 35 years, affecting more than one in five adults across ESC member countries, with similar rates in both high and low-income countries .
The prevalence of obesity and diabetes has increased two- to three-fold over the last 30 years, making it unlikely that the World Health Organization (WHO) 2025 targets to halt rises in these risk factors will be achieved. Middle-income countries report higher median age-standardized prevalence rates for hypertension, diabetes, and smoking among males compared to high-income countries.
Encouragingly, there have been variable declines in hypertension, smoking, and alcohol consumption. The reduction in smoking from 28% to 21% over the last 20 years is on track to meet WHO targets.
The American Heart Association (AHA) provides annual updates on heart disease and stroke statistics in the United States. The 2023 update highlights the ongoing challenges posed by structural racism, which significantly impacts cardiovascular health disparities. The report also includes data on the effects of COVID-19 on cardiovascular health and emphasizes the importance of health equity.
The AHA reports cover a wide range of cardiovascular conditions, including stroke, congenital heart disease, rhythm disorders, coronary heart disease, heart failure, and peripheral artery disease. These reports also address associated outcomes such as quality of care, procedures, and economic costs .
A systematic review of literature from 2007 to 2017 reveals that cardiovascular disease is a common comorbidity in type 2 diabetes (T2DM), affecting approximately 32.2% of individuals with T2DM. Coronary artery disease and stroke are major contributors to CVD-related mortality in this population, accounting for about half of all deaths.
Cardiovascular disease continues to be a significant global health challenge, with marked disparities between high-income and middle-income countries. Addressing these inequalities requires targeted policy initiatives to reduce population risk and improve cardiovascular healthcare delivery, particularly in under-resourced regions. The ongoing efforts by organizations like the ESC and AHA to monitor and report on CVD statistics are crucial for informing public health strategies and improving cardiovascular outcomes worldwide.
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