Cat's Claw dosage in clinical studies
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Cat's Claw Dosage in Clinical Studies: Key Findings
Standard Cat's Claw Dosage in Cancer and Arthralgia Clinical Trials
Multiple clinical studies have consistently used a dosage of 100 mg of Cat's Claw (Uncaria tomentosa) dry extract, administered three times daily (totaling 300 mg per day), for various patient populations. This regimen was applied in studies involving patients with advanced or terminal solid tumors, as well as in breast cancer patients experiencing aromatase inhibitor-induced arthralgia. Across these studies, the 100 mg three times daily dosage was well tolerated, with no significant adverse effects or grade 3/4 toxicities reported, and was considered safe for use in these populations 1234.
Cat's Claw Dosage in Osteoarthritis and Joint Health Studies
In osteoarthritis research, Cat's Claw has been studied both as a standalone treatment and in combination with other supplements. One study used a freeze-dried extract of Uncaria guianensis (a related species) at a dosage of 10 mg/ml, showing significant reduction in pain and improvement in patient and medical assessment scores within the first week of therapy, with no significant side effects or negative impact on blood or liver function . Another randomized controlled trial combined 100 mg/day of Cat's Claw extract with a mineral supplement (sierrasil) for 8 weeks, demonstrating early improvements in joint health and function, with good tolerability and no serious adverse events .
In Vitro Dosage Ranges for Immunological and Anti-Inflammatory Effects
In laboratory studies, Cat's Claw has been tested at various concentrations to assess its effects on immune function and inflammation. In vitro experiments with osteoarthritis patients' lymphocytes used concentrations ranging from 10 to 450 ppm, but did not find significant effects on lymphocyte proliferation or nitric oxide expression at these levels . Other in vitro research demonstrated that freeze-dried Cat's Claw was a potent inhibitor of TNFα production at very low concentrations (EC50 = 1.2 ng/ml), and also acted as an effective antioxidant, though these findings are not directly translatable to clinical dosing .
Safety and Tolerability of Cat's Claw Dosage
Across clinical studies, the most common oral dosage—100 mg of dry extract three times daily—was well tolerated, with no significant adverse effects or laboratory abnormalities reported. This dosage did not result in significant changes in inflammatory markers or biochemical parameters, and was considered safe for use in both cancer and osteoarthritis patients 123468.
Conclusion
Clinical studies most commonly use a dosage of 100 mg of Cat's Claw dry extract taken three times daily (total 300 mg/day) for cancer-related symptoms and joint pain, with good safety and tolerability profiles. In osteoarthritis, both 100 mg/day and higher concentrations in combination with other supplements have been studied, also showing good safety. Laboratory studies use a wide range of concentrations, but these are not directly applicable to clinical dosing. Overall, Cat's Claw at these dosages appears safe for short- to medium-term use in clinical settings.
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