Searched over 200M research papers
10 papers analyzed
These studies suggest that diabetes is associated with premature death from cardiovascular disease, cancer, infections, renal complications, and external causes, with varying impacts based on age, glycemic control, and regional factors.
19 papers analyzed
Diabetes significantly increases the risk of death from various causes, including vascular diseases, cancers, and other non-vascular conditions. Research indicates that individuals with diabetes have a higher mortality rate compared to those without the condition, with diabetes contributing to a substantial number of deaths globally .
Vascular diseases are a leading cause of death among individuals with diabetes. Studies show that diabetes doubles the risk of death from cardiovascular causes, including ischemic heart disease and stroke . Despite improvements in diabetes management, cardiovascular diseases remain a predominant cause of mortality, although the rates have declined over recent decades .
Diabetes is also associated with an increased risk of death from various cancers. Research highlights a moderate association between diabetes and cancers of the liver, pancreas, ovary, colorectum, lung, bladder, and breast . The proportional mortality from cancer among diabetic individuals has remained relatively stable over time, ranging from 16% to 20%.
Non-vascular, non-cancer causes of death are also significant among diabetic patients. These include renal disease, liver disease, infections, mental disorders, and chronic obstructive pulmonary disease (COPD) . The proportion of deaths from these causes has increased, reflecting a diversification in the causes of death among diabetic individuals .
The risk of death from diabetes-related causes varies with age and glycemic control. Younger individuals with poor glycemic control face a higher risk of mortality, particularly from cardiovascular and renal complications. Conversely, older adults with better glycemic control have a lower risk of death compared to their younger counterparts .
The impact of diabetes on mortality varies by region. For instance, in middle-income countries like Mexico, diabetes is associated with a far worse prognosis due to poor glycemic control and limited access to medical care. In these regions, diabetes accounts for a significant proportion of deaths, particularly from renal disease, cardiac disease, and infections. In contrast, high-income countries have seen a decline in diabetes-related mortality due to better management and treatment options.
Diabetes significantly contributes to mortality from a variety of causes, including vascular diseases, cancers, and other non-vascular conditions. While improvements in diabetes management have led to declines in some causes of death, the overall burden remains high, particularly in regions with poor healthcare access. Effective management and prevention strategies are essential to reduce the mortality risk associated with diabetes.
Most relevant research papers on this topic