Cetirizine hydrochloride 10mg

Pro Research Analysisby

Searched over 200M research papers

Analyzed relevant papers

Cetirizine Hydrochloride 10mg: Efficacy, Safety, and Comparative Studies

Introduction to Cetirizine Hydrochloride 10mg

Cetirizine hydrochloride 10mg is a second-generation antihistamine commonly used to treat symptoms of allergic rhinitis and chronic urticaria. It is known for its minimal sedative effects compared to first-generation antihistamines, making it a popular choice for allergy sufferers.

Efficacy in Treating Allergic Rhinitis

Comparative Efficacy with Fexofenadine

Several studies have compared the efficacy of cetirizine hydrochloride 10mg with other antihistamines. One study found that cetirizine 10mg and fexofenadine 180mg were equally effective in reducing symptoms of moderate-to-severe seasonal allergic rhinitis (SAR) . Another study confirmed that both cetirizine and fexofenadine significantly reduced total symptom scores compared to placebo, with no significant difference in efficacy between the two drugs .

Combination Therapy with Montelukast

A study comparing cetirizine alone versus a combination of cetirizine and montelukast (a leukotriene receptor antagonist) found that the combination therapy was more effective in treating allergic rhinitis. Patients receiving the combination therapy showed greater improvement in symptoms and fewer side effects, such as sedation, compared to those receiving cetirizine alone .

Efficacy in Treating Chronic Urticaria

Standard and Increased Dosage

Cetirizine hydrochloride 10mg has also been shown to be effective in treating chronic idiopathic urticaria. In cases where the standard dose was insufficient, doubling the dose to 20mg significantly improved symptoms such as wheal and itching, and enhanced the quality of life for patients . Another study confirmed the efficacy of cetirizine in treating urticaria, with a high efficacy rate and minimal side effects .

Safety and Side Effects

Sedation and Drowsiness

While cetirizine is generally considered a non-sedating antihistamine, some studies have reported instances of drowsiness. In a comparative study, patients taking cetirizine reported higher levels of drowsiness compared to those taking fexofenadine 12. However, the overall incidence of drowsiness with cetirizine was still relatively low.

Quality Control and Bioequivalence

Quality control studies have shown that various brands of cetirizine hydrochloride 10mg tablets meet pharmacopoeia standards for parameters such as weight variation, disintegration, and dissolution 58. Bioequivalence studies have confirmed that both domestic and imported cetirizine tablets are bioequivalent, ensuring consistent efficacy and safety across different brands 710.

Conclusion

Cetirizine hydrochloride 10mg is an effective and safe option for treating allergic rhinitis and chronic urticaria. It offers comparable efficacy to other antihistamines like fexofenadine, with the added benefit of minimal sedation. Combination therapy with montelukast can further enhance its efficacy in treating allergic rhinitis. Quality control and bioequivalence studies support the reliability of cetirizine across different brands, making it a trusted choice for allergy management.

Sources and full results

Most relevant research papers on this topic

Fexofenadine hydrochloride, 180 mg, exhibits equivalent efficacy to cetirizine, 10 mg, with less drowsiness in patients with moderate-to-severe seasonal allergic rhinitis.

Once-daily fexofenadine hydrochloride, 180 mg, provides equivalent symptom relief and significantly less drowsiness compared to cetirizine, 10 mg, in patients with moderate-to-severe seasonal allergic rhinitis.

RCTLarge Human Trial

2003·

52citations

·F. Hampel et al.

Double-blind, placebo-controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal allergic rhinitis.

Once-daily fexofenadine is a valuable addition to the nonsedating H1 receptor antagonists for treating seasonal allergic rhinitis, with both doses being effective and safe.

RCTLarge Human TrialHighly Cited

1999·

161citations

·P. Howarth et al.

Treatment of chronic urticaria with cetirizine dihydrochloride a non‐sedating antihistamine

Cetirizine dihydrochloride, a non-sedating H1-antagonist, effectively treats chronic urticaria with minimal sedative or anticholinergic side effects.

RCT

1988·

69citations

·L. Juhlin et al.

Double dose of cetirizine hydrochloride is effective for patients with urticaria resistant: a prospective, randomized, non-blinded, comparative clinical study and assessment of quality of life

Doubling the dose of cetirizine may be effective in improving symptoms and quality of life for patients with urticaria resistant to the regular dose.

RCT

2013·

19citations

·Y. Okubo et al.

Evaluation of some quality parameters of five brands of Cetirizine hydrochloride tablets marketed in Abuja, Nigeria.

Cetirizine hydrochloride 10mg tablets marketed in Abuja, Nigeria, meet quality standards for hardness, friability, disintegration, and dissolution.

2022·

0citations

·Olubukola A. Odeniran et al.

A multicentre compared study of domestic cetirizine hydrochloride in the treatment of urticaria and allergic rhinitis

Domestic cetirizine HCL is as effective and safe as zyrtec in treating urticaria and allergic rhinitis.

RCT

2004·

0citations

·Q. Jun

Study on bioequivalence of cetirizine hydrochloride chewable tablets in Chinese healthy volunteers

Cetirizine hydrochloride chewable tablets are bioequivalent in Chinese healthy volunteers, with similar pharmacokinetic parameters and relative bioavailability.

RCT

2009·

0citations

·M. Cui

A COMPARATIVE QUALITY CONTROL STUDY OF CETIRIZINE HYDROCHLORIDE 10MG TABLETS ON THE ALBANIAN PHARMACEUTICAL MARKET

All cetirizine hydrochloride 10mg tablets met pharmacopoeia standards, but the reference product sells well on the open pharmaceutical market despite having similar qualities to other generics.

2014·

7citations

·Delina Xhafaj et al.

COMPARATIVE STUDY OF SECOND GENERATION ANTI HISTAMINE (Cetirizine Hydrochloride 10mg) ALONE VERSUS ANTIHISTAMINE IN COMBINATION WITH LEUKOTRIENE RECEPTOR ANTAGONISTS (Montelukast Sodium 10mg) IN THE TREATMENT OF ALLERGIC RHINITIS

The combination of cetirizine hydrochloride 10mg/day and montelukast sodium 10mg/day is more effective in treating allergic rhinitis than cetirizine hydrochloride 10mg/day alone.

2015·

0citations

·Muhammad Ilyas et al.

Evaluation of the Bioequivalence of Domestic and Imported Cetirizine Hydrochloride Tables in Healthy Volunteers

Domestic and imported cetirizine hydrochloride tablets are bioequivalent in terms of pharmacokinetic parameters and relative bioavailability in healthy volunteers.

RCT

2002·

0citations

·Wang Ping-quan

Try another search

who invented the rocket

how long does a steroid stay in your system

ipratropium adverse effects

albuterol prescribing information

lose teeth chart

genetically altered humans