Chronic pansinusitis

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Chronic Pansinusitis: Insights and Implications

Understanding Chronic Pansinusitis

Chronic pansinusitis is a persistent inflammation affecting the mucosal lining of the nose and all paranasal sinuses. This condition is characterized by severe inflammation of the upper airways, often leading to significant discomfort and complications 12. The interconnected nature of the paranasal sinuses means that inflammation typically spreads across multiple sinus cavities, making isolated sinus disease rare .

Key Biomarkers: ADMA and Nitric Oxide Levels

Recent studies have highlighted the role of asymmetric dimethylarginine (ADMA) and nitric oxide (NO) in chronic pansinusitis. Elevated plasma levels of ADMA, a marker associated with oxidative stress, have been observed in patients with chronic pansinusitis. Conversely, these patients exhibit significantly lower levels of NO compared to healthy individuals . This imbalance suggests that increased ADMA and decreased NO levels could serve as biomarkers for oxidative stress in chronic pansinusitis, potentially aiding in diagnosis and management .

Diagnostic and Treatment Approaches

Diagnostic Criteria

Diagnosis of chronic pansinusitis typically involves a combination of clinical examination, nasal endoscopy, and imaging techniques such as computed tomography (CT) scans. These methods help confirm the extent of sinus involvement and identify any complications, such as mucoceles or polyps 346. In some cases, transillumination and palpation may also be used to detect sinus opacities and edematous conditions .

Surgical and Medical Management

Surgical intervention is often necessary for chronic pansinusitis, especially in cases resistant to medical treatment. Procedures such as endoscopic sinus surgery can provide significant and lasting relief by improving sinus drainage and removing obstructions 47. Postoperative care typically includes long-term medical therapy to manage symptoms and prevent recurrence .

Complications and Associated Conditions

Chronic pansinusitis can lead to severe complications if left untreated. These include intracranial issues like cerebral abscesses and preseptal cellulitis, which require prompt medical attention . Additionally, chronic pansinusitis is frequently associated with conditions such as cystic fibrosis (CF) and primary ciliary dyskinesia (PCD). These conditions impair mucociliary clearance, leading to persistent sinus infections and other respiratory issues 479.

Conclusion

Chronic pansinusitis is a complex condition with significant implications for patient health. Understanding the role of biomarkers like ADMA and NO, along with effective diagnostic and treatment strategies, is crucial for managing this condition. Surgical intervention, combined with long-term medical therapy, remains a cornerstone of treatment, especially in complicated cases. Awareness of associated conditions such as CF and PCD can further aid in comprehensive patient care.

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Most relevant research papers on this topic

Plasma Asymmetrıc Dımethylargınıne (ADMA) and Nıtrıc Oxıde (NO) Levels ın Patıents wıth Chronıc Pansınusıtıs

Increased plasma levels of ADMA and decreased nitric oxide levels are associated with chronic pansinusitis, potentially indicating increased oxidative stress in patients.

RCT

2021·

0citations

·Fuat Bulut et al.

XVI Pertinent Facts Relating to Chronic Pansinusitis

Chronic pansinusitis is common and often involves both nasal and paranasal sinuses, making disease limited to one cavity a rare occurrence.

1939·

2citations

·William Mithoefer

[A case of chronic pyopolypous pansinusitis with mucopyocele of the frontal sinus].

Chronic pyopolypous pansinusitis with mucopyocele of the frontal sinus is a rare but potentially treatable condition.

Case Report

2011·

0citations

·A. I. Kriukov et al.

Patterns of Sinusitis in Cystic Fibrosis

Children with cystic fibrosis can have two distinct patterns of sinus disease, chronic sinusitis and polyposis, with surgery providing lasting improvement in both cases.

Case ReportHighly Cited

1996·

114citations

·Victor G. Gentile et al.

[Pansinusitis: approach to its etiopathogenesis].

Local factors and external conditions are determinants for pansinusitis. We present 10 cases in which 20% are of unknown origin, 30% have allergic antecedents, 20% show hypersensitivity to aspirin, 20% have an immotile-cilia syndrome and 10% are caused by exogenous factors. Surgical treatment is performed in 70% of the cases, always followed by a long-term medical therapy. Forty per cent of the cases show a chronic progress despite the type of treatment applied.

Case Report

1995·

0citations

·M. Armengot et al.

LIV. External Radical Operation for Chronic Empyema of the Air Sinuses by the Orbital Route

Chronic purulent pansinusitis of the nasal accessory sinuses is a difficult and potentially incurable condition, with surgical access often necessitating an orbital approach.

1912·

0citations

·W. S. Bryant

[Polypous pansinusitis with the deformation of the external nose in a 8 year-old child presenting with the primary ciliary dyskinesia syndrome].

Chronic polypous pansinusitis with external nasal deformation in a child with primary ciliary dyskinesia syndrome can be effectively managed with endoscopic endonasal pansinusotomy, antibacterial therapy, and hormonal therapy.

Case Report

2017·

2citations

·A. Asmanov et al.

Upper respiratory disease, sinusitis, and polyposis.

Chronic pansinusitis and nasal polyposis in cystic fibrosis patients may be linked to deteriorating pulmonary status, requiring adequate management to minimize symptoms and complications.

1991·

33citations

·V. V. King

Atypical Sinusitis in Adults Must Lead to Looking for Cystic Fibrosis and Primary Ciliary Dyskinesia

Adults with atypical chronic sinusitis should be tested for primary ciliary dyskinesia and cystic fibrosis, as mucociliary clearance dysfunction may be involved.

2004·

49citations

·André Coste et al.

Pansinusitis kronis dengan komplikasi abses serebri dan selulitis preseptal: laporan kasus

Chronic pansinusitis can lead to intracranial complications, such as cerebral abscess and preseptal cellulitis, requiring immediate medical attention.

Case Report

2021·

0citations

·Iriana Maharani et al.

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