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10 papers analyzed
These studies suggest chronic stress alters physiological functions by affecting the neuroendocrine and immune systems, inflammation, and brain function, contributing to increased risks of cancer, cardiovascular disease, psychiatric disorders, and neurodegenerative diseases.
20 papers analyzed
Chronic stress is a prolonged and constant feeling of stress that can negatively affect an individual's health if it goes untreated. It has been linked to a variety of physiological dysfunctions and increased risk of numerous diseases, including cardiovascular disease, cancer, neuropsychiatric disorders, and neurodegenerative diseases. This synthesis aims to present the key insights from multiple research papers on how chronic stress alters physiological functions and contributes to disease risk.
Activation of Neuroendocrine Systems and Immune Dysfunction:
Inflammation and Immune System Alterations:
Neuropsychiatric and Neurodegenerative Disorders:
Cardiovascular Disease:
Epigenetic and Transcriptional Changes:
Chronic stress significantly alters physiological functions through the activation of neuroendocrine systems, induction of a proinflammatory state, and long-lasting changes in gene expression. These alterations contribute to the increased risk of various diseases, including cancer, cardiovascular disease, neuropsychiatric disorders, and neurodegenerative diseases. Effective stress management and therapeutic interventions targeting these pathways may help mitigate the adverse health effects associated with chronic stress.
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